New hope for prostate cancer: adding local treatment to drug therapy may delay progression

NCT ID NCT05649943

Recruiting now Disease control Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 29 times

Summary

This study is for men with metastatic hormone-sensitive prostate cancer that has spread to a limited number of sites. It compares standard drug therapy (apalutamide plus hormone therapy) to the same drugs plus a local treatment like radiation or surgery to the prostate. The goal is to see if the combined approach delays cancer growth and reduces complications. About 566 participants will be enrolled across Italy.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

ASST Santi Paolo e Carlo
NOT_YET_RECRUITING

Milan, Lombardy, 20153, Italy

Contact Email: •••••@•••••

Contact
European Institute of Oncology
NOT_YET_RECRUITING

Milan, Lombardy, 20141, Italy

Contact Email: •••••@•••••

Contact
Istituto Tumori Milano
RECRUITING

Milan, Mi, 20156, Italy

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact

Conditions

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METASTATIC HORMONE-SENSITIVE PROSTATE CANCER (MHSPC)