New drug combo aims to halt blindness from 'Dry' macular degeneration

NCT ID NCT07215390

Recruiting now Disease control Sponsor: Apellis Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tests whether adding APL-3007 to the existing drug Syfovre (pegcetacoplan) can better slow geographic atrophy, an advanced form of dry age-related macular degeneration that causes vision loss. About 240 adults aged 60 and older with the condition will receive either the combination or a placebo via eye injections. The study measures changes in retinal damage and safety over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

APL-3007 combined with pegcetacoplan (Syfovre)

What this could lead to

If successful, this combination could slow or stop the progression of geographic atrophy, a leading cause of blindness in older adults.

What could go wrong

This is an early Phase 2 trial with only 240 participants, so results may not confirm benefit. The treatment involves eye injections, which carry risks like infection or inflammation.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Advance Retina Institute
RECRUITING

Bonita Springs, Florida, 34134, United States
Advanced Vision Research Institute
RECRUITING

Longmont, Colorado, 80503, United States
Advancing Research International. LLC (01090)
RECRUITING

Indianapolis, Indiana, 46214, United States
Associated Retina Consultants (01065)
RECRUITING

Gilbert, Arizona, 85297, United States
Associated Retina Consultants - Phoenix
RECRUITING

Phoenix, Arizona, 85020, United States
Austin Retina Associate (01046)
RECRUITING

San Marcos, Texas, 78666, United States
Austin Retina Associates
RECRUITING

Austin, Texas, 78705, United States
Austin Retina Associates - Round Rock (01032)
RECRUITING

Round Rock, Texas, 78681, United States
Barnet Dulaney Perkins Eye Center (01018)
RECRUITING

Mesa, Arizona, 85206, United States
Bay Area Retina Associates - Walnut Creek
RECRUITING

Walnut Creek, California, 94598, United States
California Retina Consultants (01054)
RECRUITING

Oxnard, California, 93036, United States
California Retina Consultants (CRC) - Bakersfield Office
RECRUITING

Bakersfield, California, 93309, United States
Cascade Medical Research Institute, LLC (01070)
RECRUITING

Springfield, Oregon, 97477, United States
Center for Retina and Macular Disease (01026)
RECRUITING

Winter Haven, Florida, 33880, United States
Charleston Neuroscience Institute (01037)
RECRUITING

Beaufort, South Carolina, 29902, United States
Charleston Neuroscience Institute LLC - Ladson
RECRUITING

Ladson, South Carolina, 29456, United States
Charleston Neuroscience Institute, LLC - Mount Pleasant (01051)
RECRUITING

Mt. Pleasant, South Carolina, 29464, United States
ClearVista Clinical Research, LLC (01096)
RECRUITING

Bayonet Point, Florida, 34667, United States
Colorado Retina Associates, PLLC
RECRUITING

Lakewood, Colorado, 80228, United States
Connecticut Eye Consultants, PC (01074)
RECRUITING

Danbury, Connecticut, 06810, United States
Cumberland Valley Retina Consultants (CVRC)
RECRUITING

Hagerstown, Maryland, 21740, United States
Envision Ocular, LLC (01027)
RECRUITING

Bloomfield, New Jersey, 07003, United States
Eye Associates of Pinellas (01020)
RECRUITING

Pinellas Park, Florida, 33782, United States
Eye Care Specialists
RECRUITING

Kingston, Pennsylvania, 18704, United States
EyeHealth Northwest
RECRUITING

Portland, Oregon, 97225, United States
EyeHealth Northwest (01006)
RECRUITING

Portland, Oregon, 97228, United States
Florida Retina Institute (01053)
RECRUITING

Orlando, Florida, 32806, United States
Florida Retina Institute - Orlando (01053)
RECRUITING

Orlando, Florida, 32806, United States
Illinois Retina Associates, S.C. - Oak Park (01061)
RECRUITING

Oak Park, Illinois, 60304, United States
Long Island Vitreoretinal Consultants (01050)
RECRUITING

Great Neck, New York, 11021, United States
Long Island Vitreoretinal Consultants - Westbury
RECRUITING

Long Island City, New York, 11590, United States
Mid Atlantic Retina (01039)
RECRUITING

Cherry Hill, New Jersey, 08034, United States
Mid Atlantic Retina - Philadelphia (01017)
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Midwest Eye Institute (01066)
RECRUITING

Carmel, Indiana, 46032, United States
Mississippi Retina Associates
RECRUITING

Madison, Mississippi, 39110, United States
NJ Retina (01030)
RECRUITING

Toms River, New Jersey, 08755, United States
NJ Retina (01031)
RECRUITING

Edison, New Jersey, 08820, United States
Ophthalmology Ltd. (01084)
RECRUITING

Sioux Falls, South Dakota, 57108, United States
Orange County Retina Medical Group
RECRUITING

Santa Ana, California, 92705, United States
Piedmont Eye Center (01097)
RECRUITING

Lynchburg, Virginia, 24502, United States
Research Network Arizona
RECRUITING

Scottsdale, Arizona, 46214, United States
Retina Assocaites of Cleveland, Inc (01048)
RECRUITING

Cleveland, Ohio, 44122, United States
Retina Associates New Orleans - Jefferson Parish Location
RECRUITING

Metairie, Louisiana, 70001, United States
Retina Associates of Cleveland
RECRUITING

Cleveland, Ohio, 44130, United States
Retina Associates of Utah (01052)
RECRUITING

Salt Lake City, Utah, 84107, United States
Retina Center of Texas - Southlake
RECRUITING

Southlake, Texas, 76092, United States
Retina Consultants P.C.
RECRUITING

Indianapolis, Indiana, 46214, United States
Retina Consultants San Diego
RECRUITING

Poway, California, 92064, United States
Retina Consultants of Carolina, PA (01073)
RECRUITING

Greenville, South Carolina, 29605, United States
Retina Consultants of Orange County - Fullerton Office
RECRUITING

Fullerton, California, 93825, United States
Retina Consultants of Texas (01055)
RECRUITING

Schertz, Texas, 78154, United States
Retina Consultants of Texas - Abilene (01035)
RECRUITING

Abilene, Texas, 79606, United States
Retina Consultants of Texas - Bellaire (01067)
RECRUITING

Bellaire, Texas, 77401, United States
Retina Consultants of Texas - Katy
RECRUITING

Katy, Texas, 77494, United States
Retina Consultants of Texas - San Antonio Medical Center
RECRUITING

San Antonio, Texas, 78240, United States
Retina Consultants of Texas - The Woodlands
RECRUITING

The Woodlands, Texas, 73384, United States
Retina Macula Institute
RECRUITING

Torrance, California, 90503, United States
Retina Specialists
RECRUITING

Towson, Maryland, 21204, United States
Retina Specialty Institute - Pensacola
RECRUITING

Pensacola, Florida, 32503, United States
Retina Vitreous Associates of Florida
RECRUITING

Tampa, Florida, 33617, United States
Retina Vitreous Associates of Florida (RVA) - Saint Petersburg
RECRUITING

St. Petersburg, Florida, 33711, United States
Retinal Diagnostic Center
RECRUITING

Campbell, California, 95008, United States
Retinal Research Institute, LLC (01021)
RECRUITING

Phoenix, Arizona, 85053, United States
Salehi Retina Institute, Inc dba Retina Associate or Southern California (01034)
RECRUITING

Huntington Beach, California, 92647, United States
Salehi Retina Institute, Inc. Dba Retina Associates of Southern California (01034)
RECRUITING

Huntington Beach, California, 92647, United States
Salt Lake Retina (01044)
RECRUITING

West Jordan, Utah, 84088, United States
Southeast Retina Center
RECRUITING

Augusta, Georgia, 30909, United States
Tennessee Retina, PC (01063)
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Retina Associates
RECRUITING

Dallas, Texas, 75231, United States
The Retina Care Center
RECRUITING

Baltimore, Maryland, 21209, United States
The Retina Group of Washington (01089)
RECRUITING

Chevy Chase, Maryland, 29902, United States
The Retina Partners - Encino
RECRUITING

Encino, California, 07003, United States
Tyler Retina Consultants
RECRUITING

Tyler, Texas, 75703, United States
University of Wisconsin Health - University Station Clinic
RECRUITING

Madison, Wisconsin, 53705, United States
Valley Retina Institute- McAllen (01076)
RECRUITING

McAllen, Texas, 78503, United States
Verum Research, LLC
RECRUITING

Eugene, Oregon, 97401, United States
Vision Research Center Eye Associates of New Mexico (01023)
RECRUITING

Albuquerque, New Mexico, 87109, United States
Vision Research Solutions
RECRUITING

Indianapolis, Indiana, 21044, United States