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A squirt of gel inside a dental implant could stop it from failing

NCT ID NCT05024760

Disease control Sponsor: Madigan Army Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

Dental implants can fail when bacteria leak into the hollow space inside the implant, causing infection and bone loss. This trial tests whether placing a dab of antiseptic gel — either chlorhexidine or hydrogen peroxide — inside the implant during surgery can reduce bacterial growth and lower the chance of implant failure. The study enrolls active-duty soldiers aged 18–55 who need a dental implant and compares the two gels against each other.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
antiseptic gels (chlorhexidine or hydrogen peroxide) placed inside the dental implant cavity during surgery
What this could lead to
If effective, a simple antiseptic gel placed inside the implant could lower infection rates and improve long-term implant survival.
What could go wrong
This is a very early-phase trial with a small, specific population (active-duty soldiers), so results may not apply to the general public. Both antiseptics can cause local irritation or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

97 people

The number who actually took part.

Started

Jul 2022

Finished

May 2026

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Active duty military * 18-55 years old * Over 6 months remaining at local duty station Exclusion Criteria: * Tobacco user * Medications that affect soft tissue or bone healing * Metabolic disorder that affects soft tissue or bone healing * Active periodontal disease

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis prosthesis-related infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental implant failed Implant infection Peri-implant mucositis Peri-implantitis

Contacts and locations

Locations

  • Madigan Army Medical Center

    Tacoma, Washington, 98431, United States

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