Brain insulin study reveals hidden side effects of antipsychotics

NCT ID NCT03741478

First seen Jun 01, 2026 · Last updated Jun 05, 2026 · Updated 2 times

Summary

This study looks at how a common antipsychotic drug (olanzapine) changes the way the brain uses insulin, which affects blood sugar and memory. Healthy volunteers will receive either the drug or a placebo, plus insulin or placebo nasal spray, to measure changes in glucose production and cognitive performance. The goal is to understand why antipsychotics often cause weight gain and diabetes, especially in young people.

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Contacts and locations

Locations

  • Center for Addiction and Mental Health

    Toronto, Ontario, M5T 1R8, Canada

  • University Health Network - Toronto General Hospital

    Toronto, Ontario, M5G 2C4, Canada

Conditions

Explore the condition pages connected to this study.