Can we cut back on antidepressants without harm? new study aims to find out
NCT ID NCT06796946
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a supervised, gradual reduction of antidepressants can safely lower unnecessary long-term use in adults with mild depression or anxiety. Researchers will enroll 325 people from a health center in Spain who have taken antidepressants in the past year. The goal is to see if deprescribing improves quality of life without causing a return of symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Deprescription of antidepressants (fluoxetine, citalopram, sertraline, paroxetine, escitalopram)
What this could lead to
If successful, this could show that many people can safely reduce or stop antidepressants without worsening anxiety or depression, leading to better quality of life and fewer side effects.
What could go wrong
This is an early-phase trial with only 325 participants, so results may not apply to everyone. Some people might experience withdrawal symptoms or a return of depression or anxiety during dose reduction.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DEPRESCRIPTION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Antonio José Madueño-Caro
Cadiz, 11006, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
Contact
Contact