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Can a common antibiotic shield mothers and babies from infection?

NCT ID NCT06849037

Prevention Sponsor: Western Galilee Hospital-Nahariya Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

Researchers are testing whether giving the antibiotic zinacef during labor lowers infections for women with meconium-stained amniotic fluid at term and for their newborns. The trial enrolls 182 women with a single full-term pregnancy and meconium in the fluid. Half receive zinacef intravenously and half receive a saline placebo, and neither the women nor the doctors know who gets which. The team tracks infections like chorioamnionitis and endometritis, plus fever during labor, newborn antibiotic use, and NICU admissions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
zinacef, a cephalosporin antibiotic given intravenously
What this could lead to
If it works, giving antibiotics during labor could become a routine way to lower infection risk for women with meconium-stained fluid and their newborns.
What could go wrong
The trial is small and single-center, so results may not apply broadly. Antibiotics can cause allergic reactions or side effects, and unnecessary use may promote resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 182 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * singleton pregnancy at term * meconium-stained amniotic fluid Exclusion Criteria: * Intrauterine fetal death * GBS carriers * zinacef allergy * antibiotic treatment for other indication

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Conditions

The condition(s) this trial relates to.

chorioamnionitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chorioamnionitis Meconium-stained amniotic fluid

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Galilee Medical center

    RECRUITING

    Nahariya, Israel

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