Which antibiotic cocktail best shields vascular surgery patients from MRSA?
NCT ID NCT00967941
First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time
Summary
Researchers are comparing two antibiotic combinations given before vascular surgery to see which better prevents MRSA infections. Adults scheduled for procedures such as carotid surgery or dialysis access creation receive either vancomycin plus cefazolin or daptomycin plus cefazolin. The trial tracks how many participants develop MRSA infections and whether infections occur after groin procedures. The goal is to find the most effective preventive approach for this surgical population.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- antibiotics vancomycin or daptomycin, each given with cefazolin, before vascular surgery
- What this could lead to
- If one antibiotic combination works better, it could give surgeons a clearer way to prevent MRSA infections after vascular operations.
- What could go wrong
- This is a single-center study of 169 people, so its results may not apply everywhere. Antibiotics can cause allergic reactions or kidney problems, and they may not stop every infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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169 people
The number who actually took part.
- Start date
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Aug 2007
- Finished
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Aug 2010
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients 18 years of age and older undergoing a vascular surgery and or vascular access (vascular fistula or vascular graft) procedure were eligible for enrollment in the study.
- Ages
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18 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients greater than 18 years of age undergoing vascular surgery including carotid procedures and a vascular access procedure (Fistula or Graft). Exclusion Criteria: * Patients with an allergy to daptomycin or vancomycin. * Patients with chronic wounds. * Prior colonization of MRSA. * Increased MRSA rate facility wide. * Continuous inpatient stay \>27 hrs prior to surgical procedure. * Patients with active infection requiring antibiotics preoperatively. * Patients with a history of MRSA colonization or infection, HIV, admission for \>3 months in an acute care center or long-term care center, penicillin allergy or penicillin allergy and on dialysis. * Dialysis patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Vascular Center of Excellence
Charleston, West Virginia, 25304, United States