New powder mix aims to stop dangerous bone infections after surgery

NCT ID NCT04597008

Completed Prevention Sponsor: Major Extremity Trauma Research Consortium Source: ClinicalTrials.gov ↗

Summary

This large study tested whether adding a second antibiotic powder (Tobramycin) to a standard one (Vancomycin) in surgical wounds could better prevent deep infections after repairing serious leg fractures. It involved 1,550 adults with high-risk fractures of the shin bone. Researchers compared infection rates over six months to see if the two-powder combination was safer and more effective.

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Contacts and locations

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Locations

Atrium Health Wake Forest Baptist

Winston-Salem, North Carolina, 27157, United States
Baylor Scott & White Research Institute

Dallas, Texas, 75246, United States
Carolinas Medical Center/Atrium Health Musculoskeletal Health Institute

Charlotte, North Carolina, 28203, United States
Cedars Sinai

West Hollywood, California, 90069, United States
Core Well Health

Grand Rapids, Michigan, 49503, United States
Dartmouth Hitchcock

Lebanon, New Hampshire, 03766, United States
Harvard/Mass General/Brigham Hospitals

Boston, Massachusetts, 02115, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Indiana University School of Medicine - Methodist Hospital

Indianapolis, Indiana, 46202, United States
Indiana University/Eskenazi Health

Indianapolis, Indiana, 46202, United States
Inova Fairfax MEdical Campus

Falls Church, Virginia, 22042, United States
Jamaica Hospital Medical Center

Queens, New York, 11418, United States
Keck School of Medicine of USC

Los Angeles, California, 90033, United States
LSU Health Sciences

New Orleans, Louisiana, 70112, United States
Loyola University Chicago

Chicago, Illinois, 60153, United States
METROHealth

Cleveland, Ohio, 44109, United States
Medical University of South Carolina -

Charleston, South Carolina, 29425, United States
New York Presbyterian/Hospital for Special Surgery

New York, New York, 10021, United States
Ohio State University Wexner Medical Center

Columbus, Ohio, 43201, United States
Penn State College of Medicine

Hershey, Pennsylvania, 17033, United States
Rhode Island Hospital/Brown University

Providence, Rhode Island, 02905, United States
St Mary's University/Tenent Health

West Palm Beach, Florida, 33407, United States
Stanford University

Redwood City, California, 94063, United States
Temple University

Philadelphia, Pennsylvania, 19140, United States
UT Health San Antonio

San Antonio, Texas, 78229, United States
UTHealth/McGovern Medical School

Houston, Texas, 77030, United States
University of Alabama Heersink School of Medicine

Birmingham, Alabama, 35205, United States
University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States
University of Kentucky

Lexington, Kentucky, 40506, United States
University of Maryland Shock Trauma Center

Baltimore, Maryland, 21201, United States
University of Maryland Shock Trauma/Capitol Regions

Baltimore, Maryland, 21201, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27514, United States
University of Oklahoma College of Medicine

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania Perelman School of Medicine

Philadelphia, Pennsylvania, 19106, United States
University of Utah

Salt Lake City, Utah, 84108, United States
University of Virginia

Charlottesville, Virginia, 22903, United States
University of Wisconsin

Madison, Wisconsin, 53705, United States
Vanderbilt University

Nashville, Tennessee, 37232, United States
Virginia Commonwealth University Medical Center

Richmond, Virginia, 23298, United States
_University of California, San Francisco

San Francisco, California, 94110, United States

Conditions

Explore the condition pages connected to this study.

POST OPERATIVE SURGICAL SITE INFECTION