New dosing method may better prevent infections in overweight surgery patients

NCT ID NCT06005168

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looked at how to best dose an antibiotic (cefazolin) in overweight patients having surgery to prevent infections. Researchers compared the standard method (dosing based on body weight) with a new method (dosing based on body composition from CT scans). They measured antibiotic levels in blood and fat tissue to see which method worked better. The study involved 57 overweight adults and found that body composition-based dosing may improve antibiotic effectiveness.

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Conditions

The condition(s) this trial relates to.

Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Michigan Hospital

    Ann Arbor, Michigan, 48108, United States