Could a simple polyp removal plus a drug replace major sinus surgery?
NCT ID NCT07200336
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two treatments for chronic sinusitis with nasal polyps: a less invasive surgery (simple polyp removal) combined with an anti-IL-5 drug (mepolizumab) versus extensive sinus surgery also with the drug. About 360 participants will be randomly assigned to one of three groups: drug alone, drug plus simple polyp removal, or drug plus extensive surgery. The goal is to see if the simpler approach works just as well, improving quality of life and nasal congestion over 1 to 3 years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mepolizumab (anti-IL-5 drug)
What this could lead to
If successful, this could offer a less invasive treatment option for chronic sinusitis with nasal polyps, reducing the need for extensive surgery.
What could go wrong
This is a Phase 4 trial, but it's not yet recruiting. The less invasive approach may not be as effective as extensive surgery, and the drug may cause side effects like injection reactions.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Affiliated Hangzhou First People's Hospital,School of Medicine, Westlake University
Hangzhou, Zhejiang, 310006, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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China-Japan Union Hospital of Jilin University
Changchun, Jilin, 130033, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Eye & ENT Hospital of Fudan University
Shanghai, Shanghai Municipality, 200031, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
Shanghai, Shanghai Municipality, 200052, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Longgang District Central Hospital of Shenzhen
Shenzhen, Guangdong, 518000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Renmin hospital of Wuhan University
Wuhan, Hubei, 430060, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, 200233, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Hospital of Qingdao University
Qingdao, Shandong, 266000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated Hospital of Yunnan University
Kunming, Yunnan, 650000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 400016, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, 350005, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, 150001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, 210029, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, 510000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Hospital of Harbin Medical University
Harbin, Heilongjiang, 150086, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Hospital of Shanxi Medical University
Taiyuan, Shanxi, 030001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••