Could a simple polyp removal plus a drug replace major sinus surgery?

NCT ID NCT07200336

Not yet recruiting Disease control Sponsor: Eye & ENT Hospital of Fudan University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two treatments for chronic sinusitis with nasal polyps: a less invasive surgery (simple polyp removal) combined with an anti-IL-5 drug (mepolizumab) versus extensive sinus surgery also with the drug. About 360 participants will be randomly assigned to one of three groups: drug alone, drug plus simple polyp removal, or drug plus extensive surgery. The goal is to see if the simpler approach works just as well, improving quality of life and nasal congestion over 1 to 3 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mepolizumab (anti-IL-5 drug)
What this could lead to: If successful, this could offer a less invasive treatment option for chronic sinusitis with nasal polyps, reducing the need for extensive surgery.
What could go wrong: This is a Phase 4 trial, but it's not yet recruiting. The less invasive approach may not be as effective as extensive surgery, and the drug may cause side effects like injection reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS WITH NASAL POLYPS (CRSWNP)

Contacts and locations

Locations

Affiliated Hangzhou First People's Hospital,School of Medicine, Westlake University

Hangzhou, Zhejiang, 310006, China
China-Japan Union Hospital of Jilin University

Changchun, Jilin, 130033, China
Eye & ENT Hospital of Fudan University

Shanghai, Shanghai Municipality, 200031, China
Guanghua Hospital of Integrated Traditional Chinese and Western Medicine

Shanghai, Shanghai Municipality, 200052, China
Longgang District Central Hospital of Shenzhen

Shenzhen, Guangdong, 518000, China
Renmin hospital of Wuhan University

Wuhan, Hubei, 430060, China
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200233, China
The Affiliated Hospital of Qingdao University

Qingdao, Shandong, 266000, China
The Affiliated Hospital of Yunnan University

Kunming, Yunnan, 650000, China
The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China
The First Affiliated Hospital of Fujian Medical University

Fuzhou, Fujian, 350005, China
The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150001, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China
The First Affiliated Hospital with Nanjing Medical University

Nanjing, Jiangsu, 210029, China
The Second Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510000, China
The Second Hospital of Harbin Medical University

Harbin, Heilongjiang, 150086, China
The Second Hospital of Shanxi Medical University

Taiyuan, Shanxi, 030001, China

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