Does anesthesia choice affect brain pressure during surgery?
NCT ID NCT07786740
First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time
Summary
This trial asks whether the type of general anesthesia used during laparoscopic gallbladder removal influences pressure inside the skull, as measured by the optic nerve sheath diameter via ultrasound. Adults aged 18-80 scheduled for this surgery will be randomly assigned to receive either intravenous anesthesia with propofol or inhaled anesthesia with sevoflurane. Researchers will track optic nerve sheath diameter, blood pressure, heart rate, oxygen levels, pain, nausea, and recovery time to see if one method is safer or more comfortable.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Two anesthesia techniques: total intravenous anesthesia with propofol and remifentanil, versus volatile anesthesia with sevoflurane.
- What this could lead to
- If one anesthesia method better controls brain pressure during surgery, it could guide safer anesthesia choices for laparoscopic procedures.
- What could go wrong
- This is a small, single-center trial, and optic nerve sheath diameter is an indirect measure of brain pressure. Results may not apply to all surgeries or patients.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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80 people
The number who actually took part.
- Started
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Jan 2023
- Finished
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May 2023
- Lead sponsor
-
A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18-80 years * American Society of Anesthesiologists (ASA) physical status I-II * Scheduled for elective laparoscopic cholecystectomy * Provided written informed consent to participate Exclusion Criteria: * Refusal to participate * Uncontrolled hypertension * Uncontrolled diabetes mellitus * History of malignancy * Severe cardiovascular disease, including congestive heart failure or myocardial infarction * Severe cerebrovascular disease, including previous stroke * Hepatic dysfunction * Renal dysfunction * Pregnancy or lactation * Intracranial space-occupying lesion or any condition predisposing to increased intracranial pressure * Known optic nerve pathology
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Isntabul Bagcilar Research and Training Hospital
Istanbul, Turkey (Türkiye)
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