Brain monitor accuracy under scrutiny: anesthesia cocktail may skew readings
NCT ID NCT07699523
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study investigates how three common anesthetic drugs—midazolam, dexmedetomidine, and esketamine—affect the Bispectral Index (BIS), a brain monitor used to gauge depth of anesthesia. Researchers will enroll 120 adults undergoing gallbladder surgery under a standard propofol-remifentanil anesthetic. By comparing BIS and raw EEG changes among the drug groups, the study aims to clarify when BIS readings may misrepresent a patient's true level of consciousness, potentially improving anesthesia safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Midazolam, Dexmedetomidine, Esketamine
- What this could lead to
- If successful, this could help anesthesiologists better interpret brain activity monitors when multiple drugs are used, potentially reducing the risk of awareness during surgery.
- What could go wrong
- This is a small, early-phase study focused on monitoring changes, not on patient outcomes. Results may not apply to other surgeries or anesthesia combinations.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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China-Japan Friendship Hospital
Beijing, Beijing Municipality, 100029, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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