New hope for frail blood cancer patients: testing a Triple-Threat drug combo

NCT ID NCT04266795

Completed Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding a new drug called pevonedistat to a standard two-drug combination works better for adults newly diagnosed with acute myeloid leukemia (AML) who are too frail for intensive chemotherapy. About 164 participants worldwide were randomly assigned to receive either the three-drug combination or the standard two-drug combination in 28-day treatment cycles. The main goal was to see which group had longer event-free survival, meaning more time without the cancer getting worse or causing death.

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Contacts and locations

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Locations

ASST di Monza - Azienda Ospedaliera San Gerardo

Monza, Lombardy, 20900, Italy
AdventHealth (Florida Hospital) - Transplant Institute

Orlando, Florida, 32804, United States
Avera Cancer Institute

Sioux Falls, South Dakota, 57105, United States
Azienda Ospedaliera Citta della Salute e della Scienza di Torino

Turin, Piedmont, 10126, Italy
Azienda Ospedaliera Universitaria Careggi

Florence, 50134, Italy
Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi

Bologna, 40138, Italy
Azienda Sanitaria Ospedaliera S Luigi Gonzaga

Orbassano, Piedmont, 10043, Italy
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
CHRU Lille

Lille, 59037, France
CHRU Nantes

Nantes, 44093, France
CHRU de Poitiers La Miletrie

Poitiers, 86021, France
CHU de Grenoble

Grenoble, 38043, France
CHU de Nice

Nice, 06202, France
Centre Hospitalier Le Mans

Le Mans, Sarthe, 72000, France
Centre Hospitalier Lyon Sud

Pierre-Bénite, 69495, France
EDOG - Institut Claudius Regaud - PPDS

Toulouse, 31059, France
Fondazione IRCCS Policlinico San Matteo di Pavia

Pavia, 27100, Italy
Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli

Reggio Calabria, Calabria, 89133, Italy
HCA Midwest Health - SCRI - PPDS

Kansas City, Missouri, 64132, United States
Hopital Avicenne

Bobigny, 93009, France
Hopital Saint Antoine

Paris, 75012, France
Hopital Saint Louis

Paris, 75475, France
Hopital de L'enfant Jesus

Québec, Quebec, G1J 1Z4, Canada
Houston Methodist Cancer Center

Houston, Texas, 77030, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029-6574, United States
Institut dHematologie de Basse Normandie

Caen, 14033, France
Instytut Hematologii i Transfuzjologii

Warsaw, Masovian Voivodeship, 02-776, Poland
Intermountain LDS Hospital

Salt Lake City, Utah, 84143, United States
Istituto Clinico Humanitas

Rozzano, Milano, 20089, Italy
Joe Arrington Cancer Research and Treatment Center

Lubbock, Texas, 79410, United States
London Health Sciences Centre

London, Ontario, N6A 5W9, Canada
MTZ Clinical Research Sp z o o

Warsaw, Masovian Voivodeship, 02-106, Poland
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Northwell Health Cancer Institute

Lake Success, New York, 11042, United States
Norton Cancer Institute - Suburban

Louisville, Kentucky, 40207, United States
Ospedale Santa Maria Della Misericordia Di Perugia

Perugia, Umbria, 06156, Italy
Ottawa Hospital

Ottawa, Ontario, K1H 8L6, Canada
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie

Lublin, 20-081, Poland
Stony Brook Medicine

Stony Brook, New York, 11794, United States
Szpital Uniwersytecki Nr 2 im. Dr Jana Biziela w Bydgoszczy

Bydgoszcz, 85-168, Poland
Szpital Uniwersytecki w Krakowie

Krakow, Lesser Poland Voivodeship, 31-501, Poland
The University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
Tom Baker Cancer Centre

Tom Baker Cancer Centre, Alberta, T2N 4N2, Canada
Tulane Medical Center

New Orleans, Louisiana, 70112, United States
UC Irvine Medical Center

Orange, California, 92868, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Alberta

Edmonton, Alberta, T6G 2G3, Canada
University of Miami Miller School of Medicine

Miami, Florida, 33136, United States
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27514-4221, United States
University of Virginia Health System

Charlottesville, Virginia, 22908, United States
Uniwersytecki Szpital Kliniczny w Bialymstoku

Bialystok, Podlaskie Voivodeship, 15-276, Poland
Uniwersyteckie Centrum Kliniczne

Gdansk, 80-952, Poland
West Virginia University Hospital

Morgantown, West Virginia, 26506, United States
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi

Lodz, Łódź Voivodeship, 93-513, Poland

Conditions

Explore the condition pages connected to this study.

ACUTE MYELOID LEUKEMIA (AML)