New drug combo aims to keep deadly blood cancer at bay

NCT ID NCT04102020

First seen Apr 14, 2026 · Last updated Apr 18, 2026 · Updated 1 time

Summary

This study tested whether adding two drugs, venetoclax and azacitidine, as ongoing 'maintenance therapy' could help prevent acute myeloid leukemia (AML) from returning in patients who had achieved remission after their initial chemotherapy. The trial involved 112 adults with newly diagnosed AML who had responded well to first-line treatment but were at higher risk of the cancer coming back. Researchers aimed to find the safest and most effective dose of this drug combination for long-term use.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 214505

    Turin, Piedmont, 10126, Italy

  • ASST Grande Ospedale Metropolitano Niguarda /ID# 213946

    Milan, Milano, 20162, Italy

  • ASST degli Spedali Civili di Brescia /ID# 214580

    Brescia, 25123, Italy

  • Academician I.P. Pavlov First St. Petersburg State Medical University /ID# 215393

    Saint Petersburg, Sankt-Peterburg, 197101, Russia

  • Aichi Cancer Center Hospital /ID# 215284

    Nagoya, Aichi-ken, 464-8681, Japan

  • Almazov National Medical Research Centre /ID# 214306

    Saint Petersburg, 197341, Russia

  • Ankara Univ Medical Faculty /ID# 214239

    Ankara, 06590, Turkey (Türkiye)

  • Barwon Health /ID# 217921

    Geelong, Victoria, 3220, Australia

  • Beijing Friendship Hospital /ID# 216455

    Beijing, Beijing Municipality, 100032, China

  • Box Hill Hospital /ID# 217622

    Box Hill, Victoria, 3128, Australia

  • CHRU Lille - Hopital Claude Huriez /ID# 217474

    Lille, Nord, 59037, France

  • CHRU Tours - Hopital Bretonneau /ID# 216186

    Tours, Indre-et-Loire, 37044, France

  • Cardiff & Vale University Health Board /ID# 215906

    Cardiff, Wales, CF14 4XN, United Kingdom

  • Centre Hospitalier de Versailles André Mignot /ID# 215157

    Le Chesnay, 78150, France

  • Centre Hospitalier de la Cote Basque /ID# 216185

    Bayonne, Pyrenees-Atlantiques, 64100, France

  • Centre Hospitalier du Mans /ID# 215148

    Le Mans, Sarthe, 72037, France

  • China Medical University Hospital /ID# 213952

    Taichung, 40447, Taiwan

  • Chinese PLA General Hospital /ID# 216286

    Beijing, Beijing Municipality, 100853, China

  • Chu Angers /Id# 215151

    Angers, 49933, France

  • Chu de Nice-Hopital L'Archet Ii /Id# 217368

    Nice, Alpes-Maritimes, 06202, France

  • Clinic of Immunopathology, SRIFCI /ID# 217937

    Novosibirsk, Novosibirsk Oblast, 630047, Russia

  • Colorado Blood Cancer Institute /ID# 214280

    Denver, Colorado, 80218, United States

  • Compassionate Cancer Care Research Group - Fountain Valley /ID# 216156

    Fountain Valley, California, 92708-7501, United States

  • Debreceni Egyetem-Klinikai Kozpont /ID# 214422

    Debrecen, Hajdú-Bihar, 4032, Hungary

  • Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 215909

    London, Greater London, E1 2ES, United Kingdom

  • Dup_Guys and St Thomas NHS Foundation Trust - Guy's Hospital /ID# 215908

    London, Greater London, SE1 9RT, United Kingdom

  • Duplicate_A.O.U. Policlinico G. Rodolico S.Marco- Presidio G.Rodolico /ID# 214802

    Catania, 95123, Italy

  • Duplicate_Azienda Ospedaliera Universitaria Federico II /ID# 214278

    Naples, 80131, Italy

  • Duplicate_Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli /ID# 213947

    Naples, 80131, Italy

  • Duplicate_Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona /ID# 213944

    Ancona, 60126, Italy

  • Duplicate_CHU Bordeaux - Hopital Haut Leveque /ID# 215150

    Pessac, Gironde, 33604, France

  • Duplicate_CHU de Nantes - Hotel Dieu /ID# 217367

    Nantes, Pays de la Loire Region, 44000, France

  • Duplicate_Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 214826

    Milan, Milano, 20122, Italy

  • Duplicate_Hokkaido University Hospital /ID# 215938

    Sapporo, Hokkaido, 060-8648, Japan

  • Duplicate_Hopital Henri Mondor /ID# 215159

    Créteil, 94000, France

  • Duplicate_Hospital Universitario Reina Sofia /ID# 214786

    Córdoba, 14004, Spain

  • Duplicate_Hospital Universitario de Navarra /ID# 214788

    Pamplona, Navarre, 31008, Spain

  • Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 213948

    Bologna, Emilia-Romagna, 40138, Italy

  • Duplicate_Instituto Catalan de Oncologia (ICO) L'Hospitalet /ID# 214715

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • Duplicate_Klinikum Chemnitz gGmbH /ID# 216073

    Chemnitz, Saxony, 09116, Germany

  • Duplicate_McGill University Health Center Research Institute /ID# 215984

    Montreal, Quebec, H4A 3J1, Canada

  • Duplicate_Nagasaki University Hospital /ID# 214916

    Nagasaki, Nagasaki, 852-8501, Japan

  • Duplicate_National Hospital Organization Kyushu Cancer Center /ID# 214841

    Fukuoka, Fukuoka, 811-1395, Japan

  • Duplicate_National Hospital Organization Mito Medical Center /ID# 214699

    Higashi Ibaraki-gun, Ibaraki, 311-3193, Japan

  • Duplicate_Norton Cancer Institute /ID# 216401

    Louisville, Kentucky, 40202-3700, United States

  • Duplicate_Ochsner Clinic Foundation-New Orleans /ID# 214583

    New Orleans, Louisiana, 70121, United States

  • Duplicate_Okayama University Hospital /ID# 214840

    Okayama, Okayama-ken, 700-8558, Japan

  • Duplicate_Prisma Health Cancer Institute-Faris Road /ID# 216066

    Greenville, South Carolina, 29605-4255, United States

  • Duplicate_Pusan National University Hospital /ID# 213941

    Busan, Busan Gwang Yeogsi, 49241, South Korea

  • Duplicate_Rush University Medical Center /ID# 218815

    Chicago, Illinois, 60612, United States

  • Duplicate_Semmelweis Egyetem /ID# 214423

    Budapest, 1085, Hungary

  • Duplicate_Shanghai Tongji Hospital /ID# 218800

    Shanghai, Shanghai Municipality, 200065, China

  • Duplicate_UCLH NHS Foundation Trust - University College Hospital /ID# 215921

    London, Greater London, NW1 2PG, United Kingdom

  • Duplicate_UMass Chan Medical School /ID# 218163

    Worcester, Massachusetts, 01655, United States

  • Duplicate_University of Alberta Hospital - Division of Hematology /ID# 215656

    Edmonton, Alberta, T6G 2B7, Canada

  • Erciyes University Medical Faculty /ID# 214240

    Kayseri, 38039, Turkey (Türkiye)

  • Fakultni Nemocnice Ostrava /ID# 214809

    Ostrava, Ostrava-mesto, 708 52, Czechia

  • Fakultní Nemocnice Brno - Jihlavská /ID# 214807

    Brno, Brno-mesto, 625 00, Czechia

  • Fox Chase Cancer Center /ID# 239372

    Philadelphia, Pennsylvania, 19111, United States

  • General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 213872

    Athens, 10676, Greece

  • General Hospital of Athens Laiko /ID# 213869

    Athens, Attica, 11527, Greece

  • General University Hospital of Alexandroupolis /ID# 213870

    Alexandroupoli, 68100, Greece

  • Gibbs Cancer Center & Research /ID# 216192

    Spartanburg, South Carolina, 29303-3040, United States

  • Gold coast University Hospital /ID# 214650

    Southport, Queensland, 4215, Australia

  • Guangdong Provincial People's Hospital /ID# 216284

    Guangzhou, Guangdong, 510080, China

  • Gulhane Askeri Tip Academy /ID# 214242

    Ankara, 06010, Turkey (Türkiye)

  • Hadassah Medical Center-Hebrew University /ID# 239700

    Jerusalem, Jerusalem, 91120, Israel

  • Henan Cancer Hospital /ID# 215566

    Zhengzhou, Henan, 450008, China

  • Hopital Avicenne - APHP /ID# 215152

    Bobigny, Île-de-France Region, 93000, France

  • Hospital Santa Creu i Sant Pau /ID# 214714

    Barcelona, 08041, Spain

  • Hospital Universitario 12 de Octubre /ID# 214789

    Madrid, 28041, Spain

  • Hospital Universitario Fundacion Jimenez Diaz /ID# 214933

    Madrid, 28040, Spain

  • Hospital Universitario Infanta Leonor /ID# 214843

    Madrid, 28031, Spain

  • Hospital Universitario Ramon y Cajal /ID# 214684

    Madrid, 28034, Spain

  • Hospital Universitario Virgen de la Victoria /ID# 214713

    Málaga, 29010, Spain

  • Institut Gustave Roussy /ID# 215158

    Villejuif, Val-de-Marne, 94805, France

  • Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 215558

    Tianjin, Tianjin Municipality, 300020, China

  • Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi /ID# 215525

    Istanbul, 34098, Turkey (Türkiye)

  • Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 215680

    Nagoya, Aichi-ken, 453-8511, Japan

  • Juravinski Cancer Centre /ID# 214623

    Hamilton, Ontario, L8V 1C3, Canada

  • Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 213953

    Kaohsiung City, 807, Taiwan

  • Karadeniz University /ID# 214241

    Trabzon, 61000, Turkey (Türkiye)

  • Kindai University Hospital /ID# 214915

    Osakasayama-shi, Osaka, 589-8511, Japan

  • Kyushu University Hospital /ID# 215286

    Fukuoka, Fukuoka, 812-8582, Japan

  • Leicester Royal Infirmary /ID# 215924

    Leicester, England, LE1 5WW, United Kingdom

  • Linkou Chang Gung Memorial Hospital /ID# 213951

    Taoyuan, 333, Taiwan

  • Liverpool Hospital /ID# 215415

    Liverpool, New South Wales, 2170, Australia

  • London Health Sciences Center- University Hospital /ID# 216055

    London, Ontario, N6A 5W9, Canada

  • MD Anderson Madrid /ID# 214477

    Madrid, 28033, Spain

  • MMCC Kommunarka /ID# 215223

    Moscow, 129301, Russia

  • Massachusetts General Hospital /ID# 217307

    Boston, Massachusetts, 02114, United States

  • Mitchell Cancer Institute /ID# 216443

    Mobile, Alabama, 36604, United States

  • NTT Medical Center Tokyo /ID# 214959

    Shinagawa-ku, Tokyo, 141-8625, Japan

  • Nanfang Hospital of Southern Medical University /ID# 215565

    Guangzhou, Guangdong, 510515, China

  • National Taiwan University Hospital /ID# 213939

    Taipei City, Taipei, 100, Taiwan

  • Nizhny Novgorod Regional Clinical Hospital named N.A. Semashko /ID# 214309

    Nizhny Novgorod, Nizhny Novgorod Oblast, 603126, Russia

  • Oncology Hematology Associates (OHA) - Springfield /ID# 216351

    Springfield, Missouri, 65807-5287, United States

  • Osaka Metropolitan University Hospital /ID# 215225

    Osaka, Osaka, 545-8586, Japan

  • Ospedale S.Eugenio /ID# 214277

    Rome, 00144, Italy

  • Ottawa Hospital Research Institute /ID# 214627

    Ottawa, Ontario, K1H 8L6, Canada

  • P. Hertsen Moscow Oncology Research Institute /ID# 214312

    Moscow, 125284, Russia

  • Pan American Center for Oncology Trials, LLC /ID# 214953

    Rio Piedras, 00935, Puerto Rico

  • Peking University International Hospital /ID# 217439

    Beijing, Beijing Municipality, 102206, China

  • Perth Blood Institute Ltd /ID# 217531

    Nedlands, Western Australia, 6009, Australia

  • Princess Alexandra Hospital /ID# 238753

    Woolloongabba, Queensland, 4102, Australia

  • Providence Portland Medical Ct /ID# 216231

    Portland, Oregon, 97213-2933, United States

  • Rabin Medical Center /ID# 239696

    Petah Tikva, 4941492, Israel

  • Regional Clinical Hospital of Yaroslavl /ID# 214318

    Yaroslavl, Tatarstan, Respublika, 150062, Russia

  • Royal Adelaide Hospital /ID# 238754

    Adelaide, South Australia, 5000, Australia

  • Rutgers Cancer Institute of New Jersey /ID# 239708

    New Brunswick, New Jersey, 08901, United States

  • Saint Louis University Cancer Center /ID# 218164

    St Louis, Missouri, 63110-2539, United States

  • Saitama Medical University International Medical Center /ID# 214823

    Hidaka-shi, Saitama, 350-1298, Japan

  • Samsung Medical Center /ID# 213940

    Seoul, Seoul Teugbyeolsi, 06351, South Korea

  • Seoul National University Bundang Hospital /ID# 215549

    Seongnam-si, Gyeonggido, 13620, South Korea

  • Seoul National University Hospital /ID# 213943

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Shaare Zedek Medical Center /ID# 239699

    Jerusalem, Jerusalem, 91031, Israel

  • Shoalhaven District Memorial Hospital /ID# 221973

    Nowra, New South Wales, 2541, Australia

  • Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 214426

    Kaposvár, Somogy County, 7400, Hungary

  • St Francis Cancer Center /ID# 216115

    Greenville, South Carolina, 29607-5253, United States

  • St George Hospital /ID# 215416

    Kogarah, New South Wales, 2217, Australia

  • St. Alphonsus Regional Medical /ID# 216424

    Boise, Idaho, 83706, United States

  • Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 214425

    Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary

  • Tangdu Hospital of The Fourth Military Medical University, PLA /ID# 216283

    Xi’an, Shanxi, 710038, China

  • Tel Aviv Sourasky Medical Center /ID# 239698

    Tel Aviv, Tel Aviv, 6423906, Israel

  • Tennessee Oncology-Nashville Centennial /ID# 218757

    Nashville, Tennessee, 37203-1632, United States

  • Texas Oncology- Baylor Charles A. Sammons Cancer Center /ID# 214584

    Dallas, Texas, 75246-2003, United States

  • The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 215564

    Hangzhou, Zhejiang, 310003, China

  • The John Theurer Cancer /ID# 215191

    Hackensack, New Jersey, 07601, United States

  • Tohoku University Hospital /ID# 214669

    Sendai, Miyagi, 9808574, Japan

  • Tom Baker Cancer Centre /ID# 214625

    Calgary, Alberta, T2N 4N2, Canada

  • Tongji Hospital Tongji Medical College of HUST /ID# 216456

    Wuhan, Hubei, 430030, China

  • Toowoomba Hospital /ID# 217922

    Toowoomba, Queensland, 4350, Australia

  • Tufts Medical Center /ID# 216110

    Boston, Massachusetts, 02111-1552, United States

  • Tulane Medical Center - New Orleans /ID# 218166

    New Orleans, Louisiana, 70112-2600, United States

  • UPMC Hillman Cancer Ctr /ID# 214051

    Pittsburgh, Pennsylvania, 15232, United States

  • Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 218046

    Wuhan, Hubei, 430022, China

  • Universitaetsklinikum Giessen und Marburg /ID# 214734

    Marburg, Hesse, 35043, Germany

  • Universitaetsklinikum Halle (Saale) /ID# 221109

    Halle, 06120, Germany

  • Universitaetsklinikum Leipzig /ID# 214440

    Leipzig, Saxony, 04103, Germany

  • Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 215173

    Lübeck, Schleswig-Holstein, 23538, Germany

  • University General Hospital Attikon /ID# 214298

    Athens, Attica, 12462, Greece

  • University General Hospital of Heraklion PA.G.N.I /ID# 214075

    Heraklion, Crete, 71500, Greece

  • University General Hospital of Patras /ID# 213871

    RION Patras Achaia, 26504, Greece

  • University Health Network_Princess Margaret Cancer Centre /ID# 214624

    Toronto, Ontario, M5G 2M9, Canada

  • University Hospitals Birmingham NHS Foundation Trust /ID# 215910

    Birmingham, B15 2TH, United Kingdom

  • University Hospitals Bristol /ID# 215911

    Bristol, BS1 3NU, United Kingdom

  • University of California, Los Angeles /ID# 219149

    Los Angeles, California, 90095, United States

  • University of Fukui Hospital /ID# 215283

    Yoshida-gun, Fukui, 910-1104, Japan

  • University of Kentucky Markey Cancer Center /ID# 215048

    Lexington, Kentucky, 40536-7001, United States

  • University of Texas MD Anderson Cancer Center /ID# 225201

    Houston, Texas, 77030, United States

  • Ustav hematologie a krevni transfuze /ID# 215137

    Prague, 128 00, Czechia

  • Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 215644

    Szombathely, Vas County, 9700, Hungary

  • Weill Cornell Medical College /ID# 214847

    New York, New York, 10065, United States

  • West China Hospital, Sichuan University /ID# 216606

    Chengdu, Sichuan, 610041, China

  • Wollongong Hospital /ID# 216071

    Wollongong, New South Wales, 2500, Australia

  • Yamagata University Hospital /ID# 214698

    Yamagata, Yamagata, 990-9585, Japan

Conditions

Explore the condition pages connected to this study.