Scientists test dual attack on aggressive leukemia
NCT ID NCT05396859
Summary
This early-stage study is testing whether two drugs—entrectinib and ASTX727—can be safely combined to treat acute myeloid leukemia (AML) that has returned or resisted treatment and has a specific genetic change (TP53 mutation). The trial involves about 13 adults and aims to find the safest dose while checking if the combination shows any signs of fighting the cancer. This is a first-step safety study, not a proven treatment.
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Contacts and locations
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Locations
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OHSU Knight Cancer Institute
Portland, Oregon, 97239, United States
Conditions
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