New drug combo aims to extend life in head and neck cancer

NCT ID NCT07276399

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Dec 24, 2025 · Last updated May 16, 2026 · Updated 21 times

Summary

This study tests whether adding the drug amivantamab to standard chemotherapy and immunotherapy can help people with advanced head and neck cancer live longer. About 500 adults who have not had prior treatment for their recurrent or metastatic cancer will take part. The goal is to see if the new combination shrinks tumors and improves survival compared to the usual treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AOU Policlinico Umberto I
RECRUITING

Roma, 00161, Italy
Act. Basada en la Inv. Del Ca
RECRUITING

Guadalajara, 44680, Mexico
Addenbrooke's Hospital
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
All India Institute of Medical Sciences
RECRUITING

New Delhi, 110029, India
Apollo Speciality Hospital, Chennai
RECRUITING

Chennai, 600035, India
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Assistance Publique - Hopitaux de Paris
RECRUITING

Paris, 75012, France
Assistance Publique Hopitaux de Marseille (AP-HM) - Hopital
RECRUITING

Marseille, 13005, France
Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia
RECRUITING

Vitória, 29043 260, Brazil
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
RECRUITING

Palermo, 90127, Italy
Beijing Cancer Hospital
RECRUITING

Beijing, 100142, China
Bhagwan Mahaveer Cancer Hospital & Research Centre
RECRUITING

Jaipur, 302017, India
Bronx Veterans Affairs Medical Center
RECRUITING

The Bronx, New York, 10468, United States
Burgenlaendische Krankenanstalten Gesellschaft M B H Klinik Oberwart
RECRUITING

Oberwart, A-7400, Austria
CO de Chihuahua
RECRUITING

Chihuahua City, 31217, Mexico
Cancer Care Specialists of Central Illinois
RECRUITING

O'Fallon, Illinois, 62269, United States
Cardiomed
RECRUITING

Cluj-Napoca, 400015, Romania
Carolina Cancer Research Center
RECRUITING

Wilson, North Carolina, 27893, United States
Castle Hill Hospital
RECRUITING

Cottingham, HU16 5JQ, United Kingdom
Central Georgia Cancer Care
RECRUITING

Macon, Georgia, 31210, United States
Centre Henri Becquerel
RECRUITING

Rouen, 76000, France
Centre Oscar Lambret
RECRUITING

Lille, 59000, France
Centrum Onkologii Ziemi Lubelskiej im sw Jana z Dukli
RECRUITING

Lublin, 20-090, Poland
Changhua Christian Hospital
RECRUITING

Changhua, 500, Taiwan
China Medical University Hospital
RECRUITING

Taichung, 404, Taiwan
Chongqing Cancer Hospital
RECRUITING

Chongqing, 400015, China
Chu Helora Hospital La Louviere Site Jolimont
RECRUITING

Haine-Saint-Paul, 7100, Belgium
Clinica de Oncologie Sf Nectarie
RECRUITING

Craiova, 200542, Romania
Clinique Victor Hugo
RECRUITING

Le Mans, 72000, France
Complejo Hosp de Navarra - Hosp de Navarra
RECRUITING

Pamplona, 31008, Spain
Cuidados Oncologicos
RECRUITING

Querétaro, 76000, Mexico
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States
Debreceni Egyetem Klinikai Kozpont
RECRUITING

Debrecen, 4032, Hungary
Dongguan People s Hospital
RECRUITING

Dongguan, 523063, China
Emory University
RECRUITING

Atlanta, Georgia, 30308, United States
European Institute of Oncology
RECRUITING

Milan, 20141, Italy
Fakultni nemocnice Hradec Kralove
RECRUITING

Hradec Králové, 500 05, Czechia
Fakultni nemocnice Kralovske Vinohrady
RECRUITING

Prague, 100 00, Czechia
Find My Cancer Cen de Inv Clin
RECRUITING

Tijuana, 22010, Mexico
Florida Cancer Specialists East
RECRUITING

West Palm Beach, Florida, 33401-3406, United States
Florida Cancer Specialists North Region
RECRUITING

St. Petersburg, Florida, 33701-4553, United States
Florida Cancer Specialists South
RECRUITING

Fort Myers, Florida, 33901, United States
Fondazione G Pascale Istituto Nazionale Tumori IRCCS
RECRUITING

Naples, 80131, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Fudan Cancer Hospital
RECRUITING

Shanghai, 200032, China
Fundacao Doutor Amaral Carvalho
RECRUITING

Jaú, 17210 080, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto - Centro Integrado de Pesquisa
RECRUITING

São José do Rio Preto, 15090-0000, Brazil
Gefarma Atrys
RECRUITING

Mexico City, 11510, Mexico
GenesisCare
RECRUITING

St Leonards, 2065, Australia
Guy's and St Thomas' NHS Foundation Trust
RECRUITING

Greater London, SE1 9RT, United Kingdom
Gyor Moson Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz
RECRUITING

Győr, 9024, Hungary
Hartford Hospital
RECRUITING

Hartford, Connecticut, 06102, United States
HealthCare Global HCG Manavata Cancer Centre
RECRUITING

Nashik, 422002, India
Hokkaido University Hospital
RECRUITING

Sapporo, 060 8648, Japan
Hosp Univ Vall D Hebron
RECRUITING

Barcelona, 08035, Spain
Hosp. Clinico Univ. de Santiago
RECRUITING

Santiago de Compostela, 15706, Spain
Hosp. Cuf Descobertas
RECRUITING

Lisbon, 1998-018, Portugal
Hosp. Gral. Univ. Gregorio Maranon
RECRUITING

Madrid, 28007, Spain
Hosp. Gral. Univ. Valencia
RECRUITING

Valencia, 46014, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hosp. Univ. Miguel Servet
RECRUITING

Zaragoza, 50009, Spain
Hospital Alemao Oswaldo Cruz
RECRUITING

São Paulo, 01323 903, Brazil
Hospital Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital de Portimao-Centro Hospitalar do Barlavento Algarvio
RECRUITING

Portimão, 8500-338, Portugal
Hunan Cancer hospital
RECRUITING

Changsha, 410013, China
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
IRCCS Policlinico San Matteo, Università degli studi di Pavi
RECRUITING

Pavia, 27100, Italy
Institut Curie
RECRUITING

Paris, 75005, France
Institut Gustave Roussy
RECRUITING

Villejuif, 94800, France
Institut Roi Albert II
RECRUITING

Woluwe-Saint-Lambert, 1200, Belgium
Institut Sainte Catherine
RECRUITING

Avignon, 84918, France
Instituto Portugues de Oncologia
RECRUITING

Porto, 4200-072, Portugal
Institutul Oncologic 'Prof Dr. Ion Chiricuta' Cluj-Napoca
RECRUITING

Cluj-Napoca, 400015, Romania
Institutul Regional de Oncologie Iasi
RECRUITING

Iași, 700483, Romania
Irmandade da Santa Casa de Misericordia de Porto Alegre
RECRUITING

Porto Alegre, 90020 090, Brazil
Ironwood Cancer and Research Center
RECRUITING

Chandler, Arizona, 85224, United States
Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Kailash Cancer Hospital and Research Centre
RECRUITING

Vadodara, 391760, India
Kansai Medical University Hospital
RECRUITING

Hirakata, 573 1191, Japan
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 833, Taiwan
Kaohsiung Medical University Chung Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201 2013, United States
Klinikum Region Hannover Klinikum Siloah
RECRUITING

Hanover, Germany
Krajska nemocnice T. Bati, a.s.
RECRUITING

Zlín, 760 01, Czechia
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island
RECRUITING

Mineola, New York, 11501, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Liga Norte Riograndense Contra O Cancer
RECRUITING

Natal, 59062 000, Brazil
Linyi Cancer Hospital
RECRUITING

Linyi, 276002, China
Liverpool Hospital
RECRUITING

Liverpool, 2170, Australia
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Monash Medical Centre
RECRUITING

Clayton, 3168, Australia
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Motol University Hospital
RECRUITING

Prague, 150 06, Czechia
Mount Vernon Cancer Centre
RECRUITING

Northwood, HA6 2RN, United Kingdom
NHO Revive Research Institute, LLC
RECRUITING

Lincoln, Nebraska, 68506, United States
Nanjing Drum Tower Hospital
RECRUITING

Nanjing, 210009, China
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy
RECRUITING

Warsaw, 02-781, Poland
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach
RECRUITING

Gliwice, 44-102, Poland
National Cancer Center Hospital
RECRUITING

Tokyo, 104 0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa, 277 8577, Japan
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
Nograd Varmegyei Szent Lazar Korhaz
RECRUITING

Salgótarján, 3100, Hungary
Nottingham City Hospital
RECRUITING

Nottingham, NG5 1PB, United Kingdom
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Oncocenter Oncologie Clinica SRL
RECRUITING

Timișoara, 300166, Romania
Oregon Health And Science University
RECRUITING

Portland, Oregon, 97239, United States
Orszagos Onkologiai Intezet
RECRUITING

Budapest, 1122, Hungary
P. y S. Oncologicos Acacias
RECRUITING

Mexico City, 03240, Mexico
Pecsi Tudomanyegyetem Klinikai Kozpont
RECRUITING

Pécs, 7624, Hungary
Peter MacCallum Cancer Centre
RECRUITING

Melbourne, 3000, Australia
Providence St Jude Medical Center
RECRUITING

Fullerton, California, 92835, United States
Royal Marsden Hospital Chelsea
RECRUITING

London, SW3 6JJ, United Kingdom
Royal Surrey County Hospital NHS Trust
RECRUITING

Guildford, GU2 7XX, United Kingdom
Rush University Medical Center Rush University Cancer Center Chicago
RECRUITING

Chicago, Illinois, 60607, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Semmelweis Egyetem
RECRUITING

Budapest, 1083, Hungary
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shanghai East Hospital
RECRUITING

Shanghai, 200120, China
Shizuoka Cancer Center
RECRUITING

Sunto Gun, 411 8777, Japan
Sichuan Cancer Hospital
RECRUITING

Chengdu, 610041, China
Sichuan Provincial Peoples Hospital
RECRUITING

Chengdu, 610072, China
Spitalul Clinic Coltea
RECRUITING

Bucharest, 030167, Romania
St Bartholomew's Hospital
RECRUITING

London, EC1A 7BE, United Kingdom
St John of God Hospital Murdoch
RECRUITING

Murdoch, 6150, Australia
Stanford University Medical Center
RECRUITING

Stanford, California, 94304, United States
Sun Yat-sen University Cancer Hospital
RECRUITING

Guangzhou, 510060, China
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
Tennessee Cancer Specialists
RECRUITING

Knoxville, Tennessee, 37909, United States
Texas Oncology - San Antonio
RECRUITING

Fredericksburg, Texas, 78624, United States
Texas Oncology-Central South
RECRUITING

Waco, Texas, 76712, United States
The Affiliated Cancer Hospital of Shandong First Medical University
RECRUITING

Jinan, 250117, China
The Affiliated Hospital of Bengbu Medical College
RECRUITING

Bengbu, 233099, China
The Cancer Hospital Affiliated to Guangxi Medical University
RECRUITING

Nanning, 530021, China
The Cancer Institute Hospital of JFCR
RECRUITING

Tokyo, 135 8550, Japan
The Clatterbridge Cancer Centre
RECRUITING

Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
The Royal Marsden NHS Trust Sutton
RECRUITING

Sutton, SM2 5PT, United Kingdom
The University of Chicago Medical Center (UCMC)
RECRUITING

Chicago, Illinois, 60637, United States
The second Xiangya Hospital of Central South University
RECRUITING

Changsha, 410011, China
Tokyo Medical University Hospital
RECRUITING

Shinjuku, 160 0023, Japan
Tongji Hospital, Tongji Medical College of HUST
RECRUITING

Wuhan, 430030, China
Tongren Hospital Outpatient Bldg
RECRUITING

Beijing, 100051, China
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
UZ Antwerpen
RECRUITING

Edegem, 2650, Belgium
Uls Gaia Espinho
RECRUITING

Vila Nova de Gaia, 4434 502, Portugal
Uls Santa Maria - Hosp. Santa Maria
RECRUITING

Lisbon, 1649 028, Portugal
Union Hospital Tongji Medical College of Huazhong University of Science and Technology
RECRUITING

Wuhan, 430048, China
Universitaetsklinikum Giessen und Marburg GmbH
RECRUITING

Giessen, 35392, Germany
Universitaetsklinikum Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitaetsklinikum Regensburg
RECRUITING

Regensburg, 93053, Germany
Universitaetsklinikum Salzburg Landeskrankenhaus
RECRUITING

Salzburg, A-5020, Austria
Universitaetsklinikum Ulm
RECRUITING

Ulm, 89075, Germany
Universitair Ziekenhuis Leuven
RECRUITING

Leuven, 3000, Belgium
University Hospital Olomouc
RECRUITING

Olomouc, 779 00, Czechia
University Hospital Ostrava
RECRUITING

Ostrava, 708 00, Czechia
University Hospital St. Poelten
RECRUITING

Sankt Pölten, A-3100, Austria
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Kentucky Medical Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Miami Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
Universitätsmedizin Rostock Zentrum für Innere MedizinKlinik III
RECRUITING

Rostock, 18057, Germany
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80 214, Poland
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States
Valkyrie Clinical Trials Murrieta
RECRUITING

Murrieta, California, 92562, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Vitaz
RECRUITING

Sint-Niklaas, 9100, Belgium
Washington University School Of Medicine
RECRUITING

St Louis, Missouri, 63108, United States
West China Hospital Sichuan University
RECRUITING

Chengdu, 610041, China
Western General Hospital
RECRUITING

Edinburgh, EH4 2XU, United Kingdom
Wielkopolskie Centrum Onkologii im. Marii Sklodowskiej-Curie
RECRUITING

Poznan, 61-866, Poland
Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi
RECRUITING

Lodz, 93-513, Poland
Wuhan University - Zhongnan Hospital
RECRUITING

Wuhan, 430071, China
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06510, United States
Yibin Second People's Hospital
RECRUITING

Yibin, 644609, China
Yunnan Cancer Hospital
RECRUITING

Kunming, 650100, China

Conditions

Explore the condition pages connected to this study.

SQUAMOUS CELL CARCINOMA OF HEAD AND NECK