New targeted drug trial offers hope for Tough-to-Treat cancers

NCT ID NCT05094336

Ongoing Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

Summary

This study is testing a new oral drug, AMG 193, for people with advanced solid tumors that have lost a specific gene called MTAP. The main goals are to find a safe dose, see how the body processes the drug, and check if it helps shrink tumors, both by itself and when given with a common chemotherapy (docetaxel). It is for adults whose cancer has spread or cannot be removed by surgery.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Aichi Cancer Center

Nagoya, Aichi-ken, 464-8681, Japan
American Oncology Partners, PA

Bethesda, Maryland, 20817, United States
Asan Medical Center

Seoul, 05505, South Korea
Boca Raton Clinical Research Medical Center Inc

Tamarac, Florida, 33321, United States
California Research Institute

Glendale, California, 91204, United States
Center for Oncology and Blood Disorders

Houston, Texas, 77030, United States
Centre Georges Francois Leclerc

Dijon, 21000, France
Centre Oscar Lambret

Lille, 59020, France
Chongqing University Cancer Hospital

Chongqing, Chongqing Municipality, 400044, China
Chris OBrien Lifehouse

Camperdown, New South Wales, 2050, Australia
City of Hope National Medical Center

Duarte, California, 91010, United States
Community Health Network MD Anderson Cancer Center - North

Indianapolis, Indiana, 46250, United States
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
D and H Cancer Research Center

Margate, Florida, 33063, United States
Duke University

Durham, North Carolina, 27710, United States
Epworth Healthcare

East Melbourne, Victoria, 3002, Australia
Fomat Medical Research

Oxnard, California, 93030, United States
Fujian Cancer Hospital

Fuzhou, Fujian, 350014, China
Goshen Health Systems

Goshen, Indiana, 46526, United States
Gustave Roussy

Villejuif, 94805, France
Henry Ford Cancer Detroit (Brigitte Harris Cancer Pavilion)

Detroit, Michigan, 48202, United States
Hopitaux Universitaires Pitie Salpetriere - Charles Foix

Paris, 75013, France
Hopitaux Universitaires de Geneve

Geneva, 1211, Switzerland
Indiana University

Indianapolis, Indiana, 46202, United States
Inselspital Bern

Bern, 3010, Switzerland
Istituto Oncologico della Svizzera Italiana

Bellinzona, 6500, Switzerland
Jessa Ziekenhuis - Campus Virga Jesse

Hasselt, 3500, Belgium
Kantonsspital Sankt Gallen

Sankt Gallen, 9007, Switzerland
Landeskrankenhaus Salzburg

Salzburg, 5020, Austria
Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation

Taoyuan District, 33305, Taiwan
Lumi Research

Kingwood, Texas, 77339, United States
Medizinische Universitaet Graz

Graz, 8036, Austria
Mengchao Hepatobiliary Hospital of Fujian Medical University

Fuzhou, Fujian, 350028, China
National Cancer Center Hospital

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East

Kashiwa-shi, Chiba, 277-8577, Japan
National Cheng Kung University Hospital

Tainan, 70403, Taiwan
National Taiwan University Hospital

Taipei, 10002, Taiwan
New York University Grossman School of Medicine and New York University Langone Hospitals

New York, New York, 10016, United States
Northwell Health Monter Cancer Center

Lake Success, New York, 11042, United States
Peter MacCallum Cancer Centre

Parkville, Victoria, 3050, Australia
Prince of Wales Hospital, Chinese University of Hong Kong

Shatin, New Territories, Hong Kong
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
Queen Mary Hospital, The University of Hong Kong

Hong Kong, Hong Kong
Roswell Park Cancer Institute

Buffalo, New York, 32224, United States
Royal Marsden Hospital

Sutton, SM2 5PT, United Kingdom
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
Sanford Oncology Clinic and Pharmacy

Sioux Falls, South Dakota, 54104, United States
Sarah Cannon Research Institute

Dallas, Texas, 75230, United States
Sarah Cannon Research Institute UK

London, W1G 6AD, United Kingdom
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea
Shanghai East Hospital

Shanghai, Shanghai Municipality, 200123, China
Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, 200433, China
South Texas Accelerated Research Therapeutics

San Antonio, Texas, 78229, United States
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
Universitaetsklinikum Halle - Saale

Halle, 06120, Germany
Universitaetsklinikum Heidelberg

Heidelberg, 69120, Germany
Universitaetsklinikum Ulm

Ulm, 89081, Germany
Universitaetsklinikum Wuerzburg

Würzburg, 97078, Germany
Universitaetsspital Zuerich

Zurich, 8091, Switzerland
Universitair Ziekenhuis Antwerpen

Edegem, 2650, Belgium
Universitair Ziekenhuis Gent

Ghent, 9000, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg

Leuven, 3000, Belgium
Universite Catholique de Louvain Cliniques Universitaires Saint Luc

Brussels, 1200, Belgium
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of California at SF

San Francisco, California, 94158, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19106, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15232, United States
University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
Virginia Cancer Specialists PC

Fairfax, Virginia, 22031, United States
Washington University

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED MTAP-NULL SOLID TUMORS