New hope for aggressive breast cancer: drug combo vs. chemo in Head-to-Head trial

NCT ID NCT04158362

First seen Sep 30, 2025 · Last updated May 12, 2026 · Updated 33 times

Summary

This phase 3 study compares two standard first treatments for women with ER+/HER2- breast cancer that has spread to organs like the liver or lungs. One group receives chemotherapy, while the other gets hormone therapy combined with a targeted drug called abemaciclib. The goal is to see which approach better delays cancer growth and maintains quality of life.

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Contacts and locations

Locations

  • Centre Eugène Marquis

    Rennes, France

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69495, France

Conditions

Explore the condition pages connected to this study.