New drug trial aims to calm agitation in Alzheimer's patients

NCT ID NCT07011745

Recruiting now Symptom relief Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a combination of two medications, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. The trial will involve 352 adults who experience significant agitation related to their Alzheimer's. Participants will receive either the active treatment or a placebo for 14 weeks to compare effects on agitation levels and safety.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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A-SHINE s.r.o.
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Pilsen, 301 00, Czechia

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AGE Centrum
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Olomouc, Olomoucký kraj, 779 00, Czechia

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Accellacare
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Long Beach, California, 90807, United States

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Agile Clinical Research Trials, LLC
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Atlanta, Georgia, 30328, United States

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Alliance Clinical -West Hills
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West Hills, California, 91307, United States

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Asan Medical Center
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Seoul, 05505, South Korea

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Auxologico IRCCS - Auxologico San Luca
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Milan, Lombardy, 20149, Italy

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Azienda Ospedaliera Spedali Civili di Brescia
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Brescia, 25123, Italy

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Azienda Ospedaliero Universitaria Pisana
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Pisa, PI, 56126, Italy

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Azienda Ospedaliero-Universitaria Policlinico Umberto I - Viale del Policlinico 155
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Rome, Lazio, 00185, Italy

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Azienda Ospedaliero-Universitaria Sant'Andrea
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Rome, Lazio, 00189, Italy

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Bayit Balev Ltd.
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Rishon Le'Tzion, 7590653, Israel

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Centre Hospitalier Régional Universitaire de Lille - Hôpital Roger Salengro
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Lille, 59037, France

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Centre Hospitalier Universitaire Toulouse - Cité de la Santé
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Toulouse, Haute-Garonne, 31000, France

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Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
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Limoges, 87042, France

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Centres Memoire de Ressources et de Recherche (CMRR) - Hopital Lariboisiere-Fernand-Widal Location
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Paris, 75010, France

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Centrum In Psyche Spersonalizowanej Psychiatrii I Terapii
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Katowice, 40-146, Poland

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Centrum Medyczne HCP Szpital im. Jana Pawla II
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Poznan, Greater Poland Voivodeship, 61-485, Poland

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Centrum Medyczne NEUROMED
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Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-163, Poland

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Chandler Clinical Trials, LLC
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Chandler, Arizona, 85224, United States

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Cornwall Partnership NHS Foundation Trust
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Redruth, TR15 3QE, United Kingdom

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Envision Trials LLC
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Bonita Springs, Florida, 34134-4154, United States

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Epic Medical Research, LLC - Carrolton
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Carrollton, Texas, 75006, United States

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Epic Medical Research, LLC - Mesquite
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Mesquite, Texas, 75150, United States

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Fondazione Policlinico Gemelli IRCCS
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Roma, 00168, Italy

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Gachon University Gil Medical Center
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Incheon, 405-760, South Korea

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Gangnam Severance Hospital, Yonsei University Health System
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Seoul, 06273, South Korea

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Hattiesburg Clinic
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Hattiesburg, Mississippi, 39402, United States

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Horizon Clinical Research Center - Houston
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Cypress, Texas, 77065, United States

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Hôpital des Charpennes - Hospices Civils de Lyon (HCL)
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Villeurbanne, Rhône, 69100, France

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IPTB Clinical Research
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Tampa, Florida, 33629, United States

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Inha University Hospital
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Incheon, Incheon Gwang'yeogsi, 22332, South Korea

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Institut neuropsychiatricke pece (INEP), Praha
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Prague, Praha 8, 18600, Czechia

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Key Clinical Research
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Bradenton, Florida, 34207, United States

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Konkuk University Medical Center
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Seoul, Seoul-teukbyeolsi [Seoul], 05030, South Korea

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Kyungpook National University Chilgok Hospital
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Deagu, Taegu-Kwangyǒkshi, 41404, South Korea

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Lancashire & South Cumbria NHS Foundation Trust
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Preston, Lancashire, PR2 9HT, United Kingdom

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Las Vegas Clinical Trials
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Las Vegas, Nevada, 89030, United States

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Les Hôpitaux Universitaires de Strasbourg - Hôpital de la Robertsau
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Strasbourg, 67091, France

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Local Institution - 2000
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Córdoba, 5000, Argentina

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Mendoza, 5502, Argentina

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Córdoba, 5000, Argentina

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Córdoba, X5003DCE, Argentina

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Buenos Aires, 1199, Argentina

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Ciudad Autonoma de Buenos Aires, Buenos Aires, 1058, Argentina

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Buenos Aires, Buenos Aires F.D., 1133, Argentina

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Santiago, Santiago Metropolitan, 7560356, Chile

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Santiago, Santiago Metropolitan, 7500710, Chile

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Santiago, Santiago Metropolitan, 8330024, Chile

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Antofagasta, 1270244, Chile

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Vitacura, Santiago Metropolitan, 2511433, Chile

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Viña del Mar, Región de Valparaíso, 2511433, Chile

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Prague, 100 000, Czechia
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Prague, 100 00, Czechia
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Montpellier, 34295, France

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Düsseldorf, 40221, Germany

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Halle, 06120, Germany

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Westerstede, 26655, Germany

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Győr, Győr-Moson-Sopron, 0, Hungary

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Budapest, 1083, Hungary
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Debrecen, 4032, Hungary

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Budapest, 1088, Hungary

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Gyöngyös, Heves County, 3200, Hungary

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Budapest, 1036, Hungary

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Budapest, 1033, Hungary

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Kalocsa, Bács-Kiskun county, 6300, Hungary

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Jerusalem, 91120, Israel

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Petch Tikva, IL, 49100, Israel

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Isernia, 86077, Italy
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Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea
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Lublin, 20-064, Poland

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Lublin, 20-064, Poland
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London, W12 0NN, United Kingdom

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Cambridge, CB21 5EF, United Kingdom

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Wolverhampton, WV4 5HN, United Kingdom

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Stafford, ST16 3SR, United Kingdom
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Kropyvnytskyi, 25491, Ukraine

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Vinnytsia, Vinnytsia Oblast, 21037, Ukraine

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Lviv, Lviv Oblast, 79021, Ukraine

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Kyiv, Kyivska Oblast, 04080, Ukraine

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Dnipro, Dnipropetrovsk Oblast, 49115, Ukraine

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Smila, Cherkasy Oblast, 20708, Ukraine

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Hlevakha, Kyiv Oblast, 08631, Ukraine

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Poltava, Poltava Oblast, 36013, Ukraine

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Lviv, Lviv Oblast, 79035, Ukraine

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Skarzhyntsi, Khmelnytskyi Oblast, 32120, Ukraine

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Lutsk, Volyn Oblast, 43005, Ukraine

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Kyiv, 01030, Ukraine

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Hlevakha, Kyiv Oblast, 08631, Ukraine

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Oleksandrivka, Odesa Oblast, 67513, Ukraine

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Odesa, 65006, Ukraine

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Lviv, Lviv Oblast, 79035, Ukraine

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Basalt, Colorado, 81621, United States
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Homestead, Florida, 33032, United States

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Long Beach, California, 90805, United States

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Milwaukee, Wisconsin, 53226, United States

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Pasadena, California, 91105, United States

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San Diego, California, 92108, United States

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Long Beach, California, 90040, United States

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Napa, California, 94558, United States

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Saint Paul, Minnesota, 55130, United States

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Chandler, Arizona, 85226-3732, United States

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Norwalk, Connecticut, 06851, United States

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Miami, Florida, 33137, United States

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Orlando, Florida, 32806, United States

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Colorado Springs, Colorado, 80907, United States

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Doral, Florida, 33122, United States

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Miami, Florida, 33165, United States

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Local Institution - 2638
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Kirkland, Washington, 98034, United States

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San Juan, 00918, Puerto Rico

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Local Institution - 2640
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San Juan, 00918-4502, Puerto Rico

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San Juan, 00917, Puerto Rico

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Canton, Ohio, 44708, United States

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Local Institution - 2644
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Valley Stream, New York, 11580, United States

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San Juan, 00918, Puerto Rico

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M2M Med
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Chorzów, 41-500, Poland

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Michigan Clinical Research Institute PC
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Ann Arbor, Michigan, 48105, United States

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NEUROHK
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Choceň, 565 01, Czechia

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Neuro Health Centrum s.r.o.
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Brno, South Moravian, 628 00, Czechia

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NeuroClin Glasgow
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Motherwell, ML1 4UF, United Kingdom

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Neuropsychiatrie
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Prague, Praha 6, 160 00, Czechia

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Pantheon Clinical Research, LLC
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Bountiful, Utah, 84010, United States

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RCMed Oddzial Sochaczew
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Sochaczew, 96-500, Poland

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Richmond Behavioral Associates
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Staten Island, New York, 10312, United States

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SMG-SNU Borame Medical Center
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Seoul, 07061, South Korea

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Sanz MC, Laniado Hospital
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Netanya, 4244916, Israel

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Seoul National University Hospital
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Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea

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Sharlin Health Neuroscience Research Center
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Ozark, Missouri, 65721, United States

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Sheffield Health and Social care NHS Foundation Trust
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Sheffield, S5 7JT, United Kingdom

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South London and Maudsley NHS Foundation Trust
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London, SE5 8AZ, United Kingdom

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Surrey and Borders Partnership NHS Foundation Trust
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Chertsey, Surrey, KT16 9AU, United Kingdom

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The Catholic University of Korea, Yeouido St.Mary's Hospital
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Seoul, 07345, South Korea

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The Chaim Sheba Medical Center
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Ramat Gan, Central District, 5262000, Israel

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The Israeli Alzheimer Medical Center
RECRUITING

Ramat Gan, 5265601, Israel

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UT Health - San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

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University of Naples Federico II
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Naples, Campania, 80131, Italy

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Velocity Clinical Research - Blue Ash
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Blue Ash, Ohio, 45242, United States

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Vestra Clinics s.r.o.
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Rychnov nad Kněžnou, 516 01, Czechia

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Vitalix Clinical
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Worcester, Massachusetts, 01608, United States

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West Clinical Research
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Morehead City, North Carolina, 28557, United States

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Conditions

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ALZHEIMER DISEASE