Hope for Alzheimer's agitation: new drug combo enters final testing

NCT ID NCT07011732

Recruiting now Symptom relief Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 27 times

Summary

This study tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults with Alzheimer's-related agitation will receive either the drug combination or a placebo. The main goal is to see if agitation symptoms improve after 14 weeks of treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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AVIX Investigacion Clinica
RECRUITING

Monterrey, Nuevo León, 64623, Mexico

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Advanced Neurology Epilepsy and Sleep Center
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El Paso, Texas, 79912, United States

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Advanced Research Center (ARC) - Anaheim
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Anaheim, California, 92805, United States

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Aiginiteio University Hospital
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Athens, Attikí, 115 28, Greece

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Boca Clinical Trials Mexico S.C.
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Guadalajara, Jalisco, 44600, Mexico

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Boston Center for Memory
RECRUITING

Newton, Massachusetts, 02459, United States

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CBH Health
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Gaithersburg, Maryland, 20877, United States

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CECPAR - Centro de Estudos Clínicos do Paraná
RECRUITING

Curitiba, Paraná, 80030-310, Brazil

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CPQuali Pesquisa Clínica
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São Paulo, 01228-000, Brazil

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Campus Neurologico Senior
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Torres Vedras, 2560-280, Portugal

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Central States Research
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Tulsa, Oklahoma, 74136, United States

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Centre for Addiction & Mental Health
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Toronto, Ontario, M6J 1H4, Canada

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Centro Hospitalar do Alto Ave
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Guimarães, 4835-044, Portugal

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Centro Medico Luquez
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Córdoba, 5006, Argentina

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Chang Gung Medical Foundation-Linkou Branch
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Taoyuan, 333, Taiwan

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Chang Gung Memorial Hospital at Kaohsiung
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Kaohsiung Niao Sung Dist, Kaohsiung, 83301, Taiwan

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Clinica Universidad de Navarra
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Pamplona, 31008, Spain

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Clinica Viver - Centro de Desospitalizacao Humana
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São Paulo, 04020-060, Brazil

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Clinical Hospital Center Split
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Split, HR-21000, Croatia

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Clinical Research Institute S.C.
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Tlalnepantla, 54055, Mexico

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Combined Research Orlando (CRO)
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Orlando, Florida, 32807, United States

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Complejo Hospitalario Ruber Juan Bravo
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Madrid, 28006, Spain

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Eginition Hospital
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Athens, 11528, Greece

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Elixia MA
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Springfield, Massachusetts, 01103, United States

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Euromedica General Clinic of Thessaloniki
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Thessaloniki, 54645, Greece

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Five Towns Neurology PC -Woodmere - 923 Broadway
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Woodmere, New York, 11598-1739, United States

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Fundacion Estudios Clinicos
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Rosario, Santa Fe Province, S2000DEJ, Argentina

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General Hospital Varazdin
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Varaždin, 42000, Croatia

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Henry Dunant Hospital Center
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Athens, Attica, 115 26, Greece

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Hope Research Network - Miami
RECRUITING

Miami, Florida, 33166, United States

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Hospital Clinico San Carlos
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Madrid, 28040, Spain

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Hospital Clinico Universitario Virgen de La Victoria
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Málaga, 29010, Spain

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Hospital General Universitario de Elche
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Elche (alicante), 03203, Spain

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Hospital Moinhos de Vento
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Porto Alegre, Rio Grande do Sul, 90560-032, Brazil

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Hospital Mutua Terrassa
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Terrassa, 8221, Spain

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Hospital Universitario De Rio Hortega
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Valladolid, 47012, Spain

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Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
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Salamanca, 37007, Spain

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Hospital Universitario de Saltillo
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Saltillo, Coahuila, 25000, Mexico

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Hospital Viamed Montecanal
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Zaragoza, 50012, Spain

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Hospital Victoria Eugenia de Sevilla
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Seville, 41009, Spain

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Imaging Endpoints
RECRUITING

Scottsdale, Arizona, 85258, United States

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Innovacion y Desarrollo en Ciencias de la Salud
RECRUITING

Mexico City, Mexico City, 14090, Mexico

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Instituto Privado Kremer
RECRUITING

Córdoba, 5004, Argentina

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Institutul de Psihiatrie Socola
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Iași, 700282, Romania

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Kaizen Brain Center
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La Jolla, California, 92037, United States

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Kingfisher Cooperative
RECRUITING

Spokane, Washington, 99201, United States

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Kuramitsu Hospital
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Fukuoka, 819-0037, Japan

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Local Institution - 1001
NOT_YET_RECRUITING

La Plata, Buenos Aires, 1900, Argentina

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Local Institution - 1002
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Mar del Plata, Buenos Aires, B7602CBM, Argentina

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Local Institution - 1003
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Buenos Aires, C1428AQK, Argentina

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Local Institution - 1004
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Córdoba, 5000, Argentina

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Local Institution - 1051
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Brasília, Federal District, 70200730, Brazil

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Local Institution - 1057
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Campinas, São Paulo, 13060-080, Brazil

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Local Institution - 1058
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Porto Alegre, Rio Grande do Sul, 90430-001, Brazil

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Local Institution - 1104
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Sofia, Sofia-Grad, 1202, Bulgaria

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Local Institution - 1150
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Montreal, Quebec, H4A 3T2, Canada

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Local Institution - 1153
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Hamilton, Ontario, ON L8M 1W9, Canada

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Local Institution - 1201
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Ioannina, 45500, Greece

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Local Institution - 1207
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Athens, 15125, Greece

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Local Institution - 1250
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Kolkata, West Bengal, 700054, India

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Local Institution - 1251
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Hyderabad, 500034, India

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Local Institution - 1252
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Hyderabad, Telangana, 500082, India

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Local Institution - 1253
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New Delhi, 110029, India

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Local Institution - 1254
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Varanasi, Uttar Pradesh, 221005, India

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Local Institution - 1255
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Ahmedabad, Gujarat, 380060, India

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Local Institution - 1256
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Delhi, 110 095, India

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Local Institution - 1301
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Hadano, Kanagawa, 257-0003, Japan

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Local Institution - 1304
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Sakai, Osaka, 590-0018, Japan

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Local Institution - 1305
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Bunkyo-ku, Tokyo, 113-8603, Japan

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Local Institution - 1308
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Shimotsuke-shi, Tochigi, 329-0498, Japan

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Local Institution - 1350
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Monterrey, Nuevo León, 66460, Mexico

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Local Institution - 1360
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Mexico City, Mexico City, 14269, Mexico

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Local Institution - 1361
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Mexico City, 10200, Mexico

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Local Institution - 1401
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Coimbra, 3049, Portugal

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Local Institution - 1404
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Lisbon, 1649-035, Portugal

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Local Institution - 1451
NOT_YET_RECRUITING

Bucharest, 010825, Romania

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Local Institution - 1459
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Bucharest, 060222, Romania

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Local Institution - 1460
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Sanpetru /Brasov, 507190, Romania

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Local Institution - 1461
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Constanța, 90123, Romania

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Local Institution - 1462
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Sibiu, 550082, Romania

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Local Institution - 1550
NOT_YET_RECRUITING

Zagreb, City of Zagreb, 10000, Croatia

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Local Institution - 1553
NOT_YET_RECRUITING

Zagreb, City of Zagreb, 10000, Croatia

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Local Institution - 1554
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Rijeka, 51000, Croatia

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Local Institution - 1602
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Miami, Florida, 33122, United States

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Local Institution - 1604
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Miami, Florida, 33186, United States
Local Institution - 1608
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Ocala, Florida, 34471, United States

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Local Institution - 1610
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Inwood, New York, 11096, United States

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Local Institution - 1618
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Miami, Florida, 33135, United States

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Local Institution - 1622
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Maitland, Florida, 32751, United States

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Local Institution - 1630
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Colorado Springs, Colorado, 80907, United States
Local Institution - 1631
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Maitland, Florida, 32751, United States

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Local Institution - 1644
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Seattle, Washington, 98122, United States

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Local Institution - 1645
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Woodmere, New York, 11598-1739, United States
Local Institution - 1652
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Columbia, South Carolina, 29205, United States
Local Institution - 1655
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Marrero, Louisiana, 70072, United States

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Local Institution - 1659
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Centerville, Ohio, 45459, United States

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Local Institution - 1661
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Savannah, Georgia, 31406, United States

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Local Institution - 1663
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Foxborough, Massachusetts, 02035-1309, United States

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Local Institution - 1664
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Princeton, New Jersey, 08540, United States

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Local Institution - 1665
NOT_YET_RECRUITING

Bloomfield Hills, Michigan, 48302, United States

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Local Institution - 1755
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London, Ontario, N6A 5W9, Canada
Local Institution - 1800
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Shanghai, Shanghai Municipality, 200025, China

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Local Institution - 1801
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Nanjing, Jiangsu, 210008, China

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Local Institution - 1802
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Guangzhou, Guangzhou Province, 510260, China

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Local Institution - 1803
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Changsha, Hunan, 410008, China

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Local Institution - 1804
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Hangzhou, Zhejiang, 310003, China

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Local Institution - 1808
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Tianjin, 300350, China

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Local Institution - 1809
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Guangzhou, Guangdong, 0, China

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Local Institution - 1810
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Beijing, Beijing Municipality, 100088, China

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Local Institution - 1812
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Kunming, 650032, China

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Local Institution - 1813
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Chongqing, Chongqing Municipality, 630014, China

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Local Institution - 1815
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Haidian District, Beijing Municipality, 100191, China

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Local Institution - 1816
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Xian, Shanxi, 710061, China

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Local Institution - 1817
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Hangzhou, 310016, China

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Local Institution - 1819
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Chengdu, Sichuan, 610041, China

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London Health Sciences Centre-Victoria Campus
RECRUITING

London, Ontario, N6A 5W9, Canada

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Mayflower Clinical Research
RECRUITING

South Dartmouth, Massachusetts, 02747, United States

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Medical Center Medconsult Pleven OOD
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Pleven, 5800, Bulgaria

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Medical Center Mladost
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Varna, 9020, Bulgaria

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Medical Center Sveti Naum EOOD
RECRUITING

Sofia, Sofia-Grad, 1113, Bulgaria

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Mid Hudson Medical Research
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New Windsor, New York, 12553, United States

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National Cheng Kung University Hospital
RECRUITING

Tainan, Taiana, 704, Taiwan

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National Hospital Organization Hizen Psychiatric Center
RECRUITING

Kanzaki-Gun Yoshinogari-Cho, Saga-ken, 842-0192, Japan

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National Taiwan University Hospital
RECRUITING

Taipei, 100229, Taiwan

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Neurociencias PRISMA A.C.
RECRUITING

San Luis Potosí City, 78216, Mexico

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Oakland Medical Research
RECRUITING

Troy, Michigan, 48085, United States

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Okayama City General Medical Center Okayama City Hospital
RECRUITING

Okayama, 700-8557, Japan

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Ontario Shores Centre For Mental Health Sciences
RECRUITING

Whitby, Ontario, L1N 5S9, Canada

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Oroitu CAE
RECRUITING

Getxo, Bizkaia, 48993, Spain

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Outpatient Clinic for Individual Practice for Specialized Medical Care in Psychiatry - Dr. Madlena Dimitrova Borisova
RECRUITING

Razgrad, 7200, Bulgaria

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PUCTrials
RECRUITING

Curitiba, Paraná, 80230-130, Brazil

Contact Phone: •••-•••-••••
Patient First MD
RECRUITING

Middletown, New Jersey, 07748, United States

Contact Phone: •••-•••-••••
Prof Dr Alexandru Obregia Clinical Psychiatric Hospital- Centrul de Sanatate Mintala
RECRUITING

Bucharest, 40874, Romania

Contact Phone: •••-•••-••••
Prof. Dr. Alexandru Obregia Psychiatry Hospital
RECRUITING

Bucharest, Bucharest, 041919, Romania
Prof. Dr. Alexandru Obregia Psychiatry Hospital
RECRUITING

Bucharest, Bucharest, 041919, Romania
Prof. Dr. Alexandru Obregia Psychiatry Hospital
RECRUITING

Bucharest, Bucharest, 041919, Romania
Prof. Dr. Alexandru Obregia Psychiatry Hospital
RECRUITING

Bucharest, Bucharest, 041919, Romania
Prof. Dr. Alexandru Obregia Psychiatry Hospital
RECRUITING

Bucharest, Bucharest, 041919, Romania
Prof. Dr. Alexandru Obregia Psychiatry Hospital
RECRUITING

Bucharest, Bucharest, 041919, Romania

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Contact Phone: •••-•••-••••

Contact Phone: •••-•••-••••

Contact Phone: •••-•••-••••
Progressive Medical Research
RECRUITING

Port Orange, Florida, 32127, United States

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Rainbow and Sea Hospital
RECRUITING

Karatsu-shi, Saga-ken, 847-0031, Japan

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Redbird Research
RECRUITING

Las Vegas, Nevada, 89119, United States

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Ruschel Medicina e Pesquisa Clínica
RECRUITING

Rio de Janeiro, 22270-060, Brazil

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Shenzhen Kangning Hospital
RECRUITING

Shenzhen, Guangdong, 518118, China

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Sunnybrook Research Institute
RECRUITING

Toronto, Ontario, M4N 3M5, Canada

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Sunwise Clinical Research
RECRUITING

Walnut Creek, California, 94596, United States

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Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan

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Teikyo University Mizonokuchi Hospital
RECRUITING

Kawasaki, Kanagawa, 213-8507, Japan

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The Memory Clinic
RECRUITING

Bennington, Vermont, 05201-9810, United States

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The Neurology Group
RECRUITING

Pomona, California, 91767, United States

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Tianjin Anding Hospital
RECRUITING

Tianjin, Tianjin Municipality, 300074, China

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Torrance Clinical Research
RECRUITING

Torrance, California, 90505, United States

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Unidade Local de Saúde de Matosinhos SA
RECRUITING

Senhora da Hora, 4464-513, Portugal

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University General Hospital "ATTIKON" - General Hospital of West Attica "H AGIA VARVARA"
RECRUITING

Chaïdári, Attikí, 124 62, Greece

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University Hospital of Patras
RECRUITING

Pátrai, Achaḯa, 26504, Greece

Contact Phone: •••-•••-••••
Wasatch Clinical Research, LLC
RECRUITING

Salt Lake City, Utah, 84107, United States

Contact Phone: •••-•••-••••
Xuanwu Hospital Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100053, China

Contact Phone: •••-•••-••••

Conditions

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ALZHEIMER DISEASE