Major heart disease trial aims to slash deaths by clearing toxic protein

NCT ID NCT06183931

Ongoing Disease control Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether the drug ALXN2220 can help adults with a serious heart condition called transthyretin amyloid cardiomyopathy (ATTR-CM). The main goal is to see if the drug reduces the combined number of deaths from any cause and serious heart-related health events, compared to a placebo. Over 1,100 participants with advanced heart failure symptoms will receive either the study drug or a placebo to measure its effectiveness and safety over time.

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Locations

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Irvine, California, 92614, United States
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La Jolla, California, 92037, United States
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Palo Alto, California, 94304, United States
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San Francisco, California, 94143, United States
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Aurora, Colorado, 80045, United States
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Washington D.C., District of Columbia, 20010, United States
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Jacksonville, Florida, 32224, United States
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Weston, Florida, 33331, United States
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Atlanta, Georgia, 30309, United States
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Atlanta, Georgia, 30322, United States
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Chicago, Illinois, 60611, United States
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Indianapolis, Indiana, 46202, United States
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Boston, Massachusetts, 02115, United States
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Boston, Massachusetts, 02118, United States
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Kansas City, Missouri, 64111, United States
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St Louis, Missouri, 63110, United States
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New York, New York, 10016, United States
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New York, New York, 10032, United States
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Stony Brook, New York, 11794, United States
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Chapel Hill, North Carolina, 27599, United States
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Durham, North Carolina, 27705, United States
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Cleveland, Ohio, 44195, United States
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Columbus, Ohio, 43210, United States
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Portland, Oregon, 97239, United States
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Danville, Pennsylvania, 17822, United States
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Philadelphia, Pennsylvania, 19104, United States
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Charleston, South Carolina, 29425, United States
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Greenville, South Carolina, 29605, United States
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Memphis, Tennessee, 38120, United States
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Fort Worth, Texas, 76104, United States
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Houston, Texas, 77030, United States
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Salt Lake City, Utah, 84132, United States
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Falls Church, Virginia, 22042, United States
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Richmond, Virginia, 23298, United States
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Seattle, Washington, 98195, United States
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Madison, Wisconsin, 53705, United States
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Buenos Aires, 1425, Argentina
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CABA, C1025ABI, Argentina
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Ciudad de Buenos Aires, C1181ACH, Argentina
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Ciudad de Buenos Aires, C1428, Argentina
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Córdoba, X5016KEH, Argentina
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Bedford Park, 5042, Australia
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Box Hill, 3128, Australia
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Brisbane, 4102, Australia
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Darlinghurst, 2010, Australia
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Joondalup, 6027, Australia
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Melbourne, 3004, Australia
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Westmead, 2145, Australia
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Vienna, 1090, Austria
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Vienna, 1160, Austria
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Wels, 4600, Austria
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Bruges, 8000, Belgium
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Brussels, 1070, Belgium
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Genk, 3600, Belgium
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Aracaju, 49015-380, Brazil
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Campinas, 13083, Brazil
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Fortaleza, 60430-375, Brazil
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Porto Alegre, 90560-030, Brazil
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Ribeirão Preto, 14026-020, Brazil
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Ribeirão Preto, 14051-140, Brazil
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Rio de Janeiro, 20551-030, Brazil
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Rio de Janeiro, 22270-005, Brazil
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São Paulo, 01323-001, Brazil
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São Paulo, 04012-909, Brazil
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São Paulo, 05403-000, Brazil
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São Paulo, 05652-900, Brazil
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Calgary, Alberta, T2N 1N4, Canada
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Winnipeg, Manitoba, R2H 2A6, Canada
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London, Ontario, N6C 2R5, Canada
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Toronto, Ontario, M5G 2C4, Canada
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Chicoutimi, Quebec, G7H 5H6, Canada
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Montreal, Quebec, H1T 1C8, Canada
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Montreal, Quebec, H2X 1R9, Canada
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Rimouski, Quebec, G5L 5T1, Canada
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Beijing, 100034, China
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Beijing, 100037, China
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Beijing, 100191, China
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Beijing, 100730, China
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Changsha, 430033, China
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Chengdu, 610000, China
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Chengdu, 610072, China
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Chongqing, 400042, China
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Fuzhou, 350005, China
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Guangzhou, 510080, China
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Guiyang, 550044, China
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Hangzhou, 310003, China
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Hangzhou, 310009, China
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Harbin, 150080, China
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Hefei, 230001, China
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Jinan, 250021, China
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Nanjing, 210029, China
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Shanghai, 201114, China
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Tianjin, 300457, China
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Wuhan, 430030, China
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Xi'an, 710061, China
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Prague, 128 08, Czechia
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Prague, 140 00, Czechia
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Aarhus, 8200, Denmark
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Odense C, 5000, Denmark
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Bron, 69677, France
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Chambray-lès-Tours, 37170, France
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Créteil, 94010, France
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Marseille, 13005, France
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Montpellier, 34295, France
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Paris, 75018, France
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Paris, 75651, France
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Pessac, 33604, France
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Poitiers, 86021, France
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Rennes, 35033, France
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Saint-Herblain, 44093, France
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Toulouse, 31059, France
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Berlin, 10117, Germany
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Cologne, 50937, Germany
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Essen, 45147, Germany
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Giessen, 35392, Germany
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Hamburg, 22767, Germany
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Hanover, 30625, Germany
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Heidelberg, 69120, Germany
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Homburg, 66421, Germany
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Kiel, 24105, Germany
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Leipzig, 04103, Germany
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München, 81377, Germany
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Münster, 48149, Germany
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Würzburg, 97078, Germany
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Athens, 11528, Greece
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Dublin, 8, Ireland
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Beer Yaakov, 70300, Israel
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Haifa, 31096, Israel
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Haifa, 34362, Israel
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Jerusalem, 91120, Israel
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Jerusalem, 9372212, Israel
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Petah Tikva, 4941492, Israel
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Rehovot, 76100, Israel
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Bologna, 40138, Italy
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Ferrara, 44124, Italy
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Florence, 50134, Italy
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Forlì, 47121, Italy
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Messina, 98124, Italy
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Milan, 20122, Italy
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Napoli, 80131, Italy
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Padua, 35128, Italy
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Pavia, 27100, Italy
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Pisa, 56124, Italy
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Roma, 00189, Italy
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Torino, 10154, Italy
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Trieste, 34128, Italy
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Bunkyō City, 113-8431, Japan
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Kumamoto, 860-8556, Japan
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Kurume-shi, 830-0011, Japan
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Kyoto, 602-8566, Japan
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Matsumoto-shi, 390-8621, Japan
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Sapporo, 060-8543, Japan
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Shinjuku-ku, 160-8582, Japan
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Suita-shi, 564-8565, Japan
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Groningen, 9713 GZ, Netherlands
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Maastricht, 6229 HX, Netherlands
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Rotterdam, 3015 GD, Netherlands
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Utrecht, 3584 CX, Netherlands
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Lørenskog, N-1478, Norway
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Oslo, 0372, Norway
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Trondheim, 7030, Norway
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Gdansk, 80-952, Poland
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Poznan, 61-848, Poland
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Warsaw, 02-097, Poland
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Busan, 49241, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Seoul, 5505, South Korea
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Wŏnju, 26426, South Korea
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A Coruña, 15009, Spain
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Barcelona, 8035, Spain
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El Palmar, 30120, Spain
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Jaén, 23007, Spain
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L'Hospitalet de Llobregat, 08907, Spain
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Madrid, 28027, Spain
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Majadahonda, 28222, Spain
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Málaga, 29010, Spain
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Palma de Mallorca, 07198, Spain
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Pamplona, 31008, Spain
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Salamanca, 37007, Spain
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Santiago de Compostela-Coruña, 15706, Spain
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Valencia, 46010, Spain
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Gothenburg, 413 45, Sweden
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Lund, 22242, Sweden
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Skellefteå, 93186, Sweden
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Stockholm, 171 64, Sweden
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Basel, 4031, Switzerland
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Bern, 3010, Switzerland
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Lucerne, 6000, Switzerland
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Sankt Gallen, 9007, Switzerland
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Zurich, 8091, Switzerland
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New Taipei City, 220, Taiwan
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Taichung, 404, Taiwan
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Taichung, 40705, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Ankara, 06230, Turkey (Türkiye)
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Dinar, 03400, Turkey (Türkiye)
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Eskişehir, 26480, Turkey (Türkiye)
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Istanbul, 34303, Turkey (Türkiye)
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Mersin, 33079, Turkey (Türkiye)
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Birmingham, B15 2SQ, United Kingdom
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Cardiff, CF15 9SS, United Kingdom
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Glasgow, G20 0SP, United Kingdom
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Hexham, NE46 1QJ, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SE1 1YR, United Kingdom
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Manchester, M15 6SE, United Kingdom

Conditions

Explore the condition pages connected to this study.

TRANSTHYRETIN AMYLOID CARDIOMYOPATHY