New drug trial aims to help people walk farther, hurt less from rare bone disease

NCT ID NCT06079281

Ongoing Disease control Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new drug called ALXN1850 can improve walking ability, strength, and reduce pain in teenagers and adults with hypophosphatasia, a rare genetic bone disorder. Participants who have never taken the existing treatment (asfotase alfa) will receive either the new drug or a placebo via injection for about 6 months. The main goal is to see if the drug helps people walk farther in 6 minutes compared to the start of the study.

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Contacts and locations

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Locations

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Indianapolis, Indiana, 46202, United States
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Garden City, New York, 11530, United States
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Durham, North Carolina, 27705, United States
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Columbus, Ohio, 43203, United States
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Nashville, Tennessee, 37212, United States
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Ciudad de Buenos Aires, C1199, Argentina
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Clayton, 3168, Australia
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Herston, 4029, Australia
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Parkville, 3052, Australia
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St Leonards, 2065, Australia
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Belo Horizonte, 30130-100, Brazil
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Brasília, 71625-009, Brazil
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Recife, 50740-465, Brazil
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Salvador, 40050-410, Brazil
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São Paulo, 01409-902, Brazil
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São Paulo, 05403-900, Brazil
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Calgary, Alberta, T2E 7Z4, Canada
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Edmonton, Alberta, T6G 2H7, Canada
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Winnepeg, Manitoba, R3E 3P4, Canada
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Oakville, Ontario, L6M 1M1, Canada
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Trois-Rivières, Quebec, G9A 4P3, Canada
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Beijing, 100039, China
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Beijing, 100730, China
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Changsha, 430033, China
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Chengdu, 610041, China
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Nanchang, 330006, China
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Qingdao, 266035, China
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Shanghai, 201306, China
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Shenzhen, 518053, China
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Paris, 75014, France
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Poitiers, 86000, France
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Bad Reichenhall, 83435, Germany
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Berlin, 10117, Germany
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Bonn, 53127, Germany
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Hamburg, 20251, Germany
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Würzburg, 97074, Germany
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Ashkelon, 7830604, Israel
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Ramat Gan, 52621, Israel
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Florence, 50139, Italy
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Milan, 20122, Italy
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Milan, 20132, Italy
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Padua, 35128, Italy
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Pisa, 56126, Italy
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San Giovanni Rotondo, 71013, Italy
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Verona, 37134, Italy
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Hiroshima, 734-8551, Japan
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Iizuka-shi, 820-8505, Japan
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Osaka, 545-8586, Japan
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Sapporo, 060-8648, Japan
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Yaizu-shi, 425-8505, Japan
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Lodz, 93-338, Poland
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Seoul, 03722, South Korea
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Seoul, 07061, South Korea
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Suwon, 16499, South Korea
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Barcelona, 08003, Spain
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Granada, 18016, Spain
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Madrid, 28046, Spain
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San Cristóbal de La Laguna, 38320, Spain
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Santander, 39008, Spain
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Vitoria-Gasteiz, 01009, Spain
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Taipei, 100, Taiwan
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Taoyuan District, 333, Taiwan
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Ankara, 06560, Turkey (Türkiye)
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Erzurum, 25240, Turkey (Türkiye)
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London, SW170QT, United Kingdom

Conditions

Explore the condition pages connected to this study.

HYPOPHOSPHATASIA