New drug switch strategy aims to outsmart tough breast cancer

NCT ID NCT07151586

First seen Oct 31, 2025 · Last updated May 14, 2026 · Updated 29 times

Summary

This study tests if switching between two different targeted drugs (sacituzumab govitecan and trastuzumab deruxtecan) can help people with a hard-to-treat, advanced breast cancer called HER2-low triple-negative breast cancer live longer. About 260 adults with metastatic or locally advanced cancer will be randomly assigned to get either the alternating drug combo or just one drug alone. The main goal is to see if the alternating approach improves overall survival.

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Contacts and locations

Study contacts

  • Contact

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Gustave Roussy

    Villejuif, 94800, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • institut Paoli calmette

    Marseille, 13009, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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