Could alternating chemo drugs boost survival in biliary cancer?
NCT ID NCT07062536
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether alternating between two chemotherapy regimens (mFOLFOX and mFOLFIRI) works better than using just one (mFOLFOX) as a second-line treatment for advanced biliary tract cancer. The study will enroll 130 adults whose cancer has progressed after first-line treatment. The main goal is to see if the alternating approach improves 6-month survival rates.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- chemotherapy drugs (oxaliplatin, 5FU, leucovorin, irinotecan)
- What this could lead to
- If successful, this could offer a more effective second-line chemotherapy option for people with advanced biliary tract cancer, potentially improving survival.
- What could go wrong
- This is a phase 2 trial with only 130 participants, so results are preliminary. Chemotherapy has significant side effects, and the alternating regimen may not prove better than standard treatment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Asan Medical Center
RECRUITINGSeoul, Seoul, 05505, South Korea
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CHA Bundang Medical Center
RECRUITINGSeongnam-si, Gyeonggi-do, 13496, South Korea
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Chonnam National University Hwasun Hospital
RECRUITINGHwasun, Jeollanam-do, 58128, South Korea
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Chungbuk National University Hospital
RECRUITINGCheongju-si, North Chungcheong, 28644, South Korea
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Dong-A University Hospital
RECRUITINGBusan, Busan, 49201, South Korea
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Gachon University Gil Medical Center
RECRUITINGIncheon, Incheon, 21565, South Korea
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Gangneung Asan Hospital
RECRUITINGGangneung, Gangwon-do, 25457, South Korea
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Keimyung University Dongsan Hospital
RECRUITINGDaegu, Daegu, 42601, South Korea
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Seoul Metropolitan Government Seoul National University Boramae MedicalCenter
RECRUITINGSeoul, Seoul, 07061, South Korea
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Seoul National University Bundang Hospital
RECRUITINGSeongnam-si, Out of US, 13605, South Korea
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Yonsei University Health System, Severance Hospital
RECRUITINGSeoul, Seoul, 03722, South Korea
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