New drug tested to slow kidney damage in rare genetic disease
NCT ID NCT06274489
Summary
This study tested whether adding an experimental drug called setanaxib to standard care could help protect kidney function in people with Alport syndrome, a rare genetic condition that damages the kidneys. Twenty patients aged 12-50 received either setanaxib or a placebo pill for 24 weeks, in addition to their usual medications. Researchers primarily checked for side effects and also measured protein in urine and other blood markers to see if the drug showed any early signs of helping the kidneys.
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Contacts and locations
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Locations
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AP-HP Hopital Necker-Enfants Malades
Paris, 75015, France
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Fakultni Nemocnice Hradec Kralove
Hradec Králové, Czechia
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Fakultni Nemocnice Olomouc
Olomouc, Czechia
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Fundacio Puigvert
Barcelona, 08025, Spain
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Great Ormond Street Hospital for Children
London, WC1N 3JH, United Kingdom
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Hospital Clinic Barcelona
Barcelona, 08036, Spain
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Hospital Fundacion Jimenez Diaz
Madrid, 28040, Spain
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Hospital Universitario 12 de Octubre
Madrid, Usera, 28041, Spain
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Hospital Universitario Reina Sofia
Córdoba, 14004, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, Spain
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Hospital Universitario Virgen de las Nieves
Granada, 18014, Spain
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Institut Klinicke a Experimentalni Mediciny
Prague, Czechia
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Medizinische Universitaet Wien
Vienna, Vienna, 1090, Austria
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Nottingham City Hospital
Nottingham, United Kingdom
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Royal Free London NHS Foundation Trust
London, NW3 2QG, United Kingdom
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Royal Manchester Children's Hospital
Manchester, M13 9WL, United Kingdom
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Vseobecna Fakultni Nemocnice v Praze
Prague, Czechia
Conditions
Explore the condition pages connected to this study.