New hope for PNH patients with stubborn anemia?
NCT ID NCT07187401
First seen Nov 01, 2025 · Last updated May 19, 2026 · Updated 27 times
Summary
This study tests an experimental drug called ALN-CFB in 24 people with paroxysmal nocturnal hemoglobinuria (PNH) who still have low red blood cells despite standard treatment. The goal is to see if ALN-CFB is safe and tolerable compared to a placebo, and how it affects blood levels of complement factor B. Participants must be on a stable dose of a C5 inhibitor and have hemoglobin at or below 10.5 g/dL.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Samsung Medical Center
RECRUITINGSeoul, 6351, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Seoul National University Hospital
RECRUITINGSeoul, 03080, South Korea
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Severance Hospital
RECRUITINGSeoul, 3722, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. James's University Hospital
RECRUITINGLeeds, West Yorkshire, LS97TF, United Kingdom
Contact Email: •••••@•••••
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St. Vincent Hospital - The Catholic University of Korea
RECRUITINGSuwon, Gyeonggi-do, 16247, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Catholic University of Korea, Seoul St. Mary's Hospital
RECRUITINGSeoul, 06591, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Toronto General Hospital
RECRUITINGToronto, Ontario, M5G 2C4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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