Personalized dosing breakthrough tested for adult leukemia treatment
NCT ID NCT00136435
Summary
This study tested whether adjusting the dose of a key chemotherapy drug (L-asparaginase) based on individual patient measurements could help adults with acute lymphoblastic leukemia complete their full treatment course. It involved 100 adults aged 18-50 who received multi-phase chemotherapy over about two years. The main goal was to see if this personalized approach made it easier for patients to finish all planned doses while monitoring survival outcomes and side effects.
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Contacts and locations
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Locations
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Hospital Maisonneuve-Rosemont
Montreal, Quebec, Canada
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London Health Sciences Centre
London, Ontario, Canada
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Manitoba Blood & Marrow Transplant Program CancerCare Manitoba
Winnipeg, Manitoba, Canada
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Massachusetts General Hospital
Boston, Massachusetts, 02115, United States
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McMaster University Medical Center
Hamilton, Ontario, Canada
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Queen Elizabeth II
Halifax, Canada
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Queen's University
Kingston, Ontario, Canada
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Royal Victoria Hospital
Montreal, Quebec, Canada
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Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada
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Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
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University Of Columbia Medical Center
New York, New York, United States
Conditions
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