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Could a workout help your brain take out the trash?

NCT ID NCT07775196

Knowledge-focused Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This study explores whether a single session of aerobic exercise can enhance the brain's glymphatic system—a network that clears waste products. Researchers will use MRI to compare brain fluid dynamics in healthy adults aged 25–75, both at rest and during exercise on a stationary bike. The goal is to understand how aging affects this cleaning process and whether exercise might help keep it running smoothly.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acute aerobic exercise on an MRI-compatible ergometer
What this could lead to
If exercise enhances the brain's waste-clearing system, it could point toward lifestyle strategies to support brain health and potentially reduce dementia risk.
What could go wrong
This is an early, observational-style interventional study, not a treatment trial. It may not prove long-term benefits, and exercise during MRI may be challenging for some participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 240 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age 25-75 years old * cognitively unimpaired (CU) * Mini-Mental State Examination (MMSE) score ≥27 at enrollment screening * matched gender * all racial/ethnic groups Exclusion Criteria: * pregnant women * history of stroke or other major cerebrovascular disease; * diagnosis of Alzheimer's disease (AD) or other types of dementia; * diagnosis of major neurologic and psychiatric disorders (e.g., Parkingson's disease, major depression); * history of prior head trauma, significant autoimmune disorders, * sleep apnea; * major systemic illness likely to affect the central nervous system, e.g., uncontrolled diabetes, severe cardiovascular disease, cancer, etc.; * prior or current alcoholism or drug abuse; * resistant hypertension (SBP ≥140 or DBP ≥ 90 mmHg despite 3 antihypertensive drugs at maximal doses); * orthostatic hypotension defined as the third standing systolic blood pressure (SBP) \< 100mmHg; any contraindications to having a MRI, e.g., claustrophobia, pacemaker or other medical device of metal; * any conditions judged by the investigators to be medically inappropriate, risky or likely to cause poor study compliance.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging and exercise impacts on glymphatic function

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.