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Gum biopsies reveal Aging's fingerprint in tissue

NCT ID NCT06167798

Knowledge-focused Sponsor: The Forsyth Institute Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers are studying how aging changes the structure and gene activity of healthy gum tissue. They will take two small biopsies from the gums of 100 healthy adults across six age groups, from age 20 to 74. The tissue samples will be analyzed to see how gene expression and cell structure differ with age. This study does not test a treatment; it aims to understand the biology of aging in the mouth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
gingival biopsy
What this could lead to
If researchers find age-related patterns in gum tissue, this could help explain why oral health changes with age and point toward ways to keep gums healthier longer.
What could go wrong
This is a small observational study of 100 people, so any patterns may not apply to everyone. Biopsies carry minor risks like bleeding or discomfort, and the study does not test any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

100 people

The number who actually took part.

Started

Apr 2012

Finished

Jun 2013

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals between the ages of 20-74 with healthy oral tissues will be included.

Ages

20 to 74 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * provide written informed consent to participate in the study. * be at the ages specified within age groups. * male or female of the Caucasian race * agree not to participate in any other oral/dental product studies during the course of this study. * agree to delay any elective dentistry (including dental prophylaxis) until the study has been completed. * agree to return for all scheduled visits and follow study procedures. * have at least 16 natural teeth (excluding wisdom teeth). * be in good general health, as determined by the Investigator/designee based on a review of the health history/update for participation in the study. * healthy gingival tissue suitable for biopsy in the maxillary premolar area (per examiner discretion). Exclusion Criteria: * use of antibiotics 3 months prior to the study * smoking or smoking cessation \<1 year; * any diseases or conditions to be expected to interfere with the examination or with the subject safely completing the study; * history of drug use that is associated with gum overgrowth (i.e., dilantin, nifedipine, etc) or drugs that are known to inhibit salivary flow (i.e. antipsychotics etc.); * chronic use of medication such as steroids, ibuprofen or acetylsalicylic acid (aspirin/ASA) more than 2-3 days/week), anti-coagulant medications, immunosuppressant medications or any other medications that in the opinion of the Investigator would interfere with the evaluation or confound interpretation of the study results. Use of low dose of ASA is permitted; * previous gum surgery that might interfere with gum biopsy collection; * presence or history of periodontal disease (at least 2 pockets 6mm); * all teeth that are grossly carious, fully crowned, or extensively restored (per investigator discretion); * any condition requiring the need for antibiotic pre-medication prior to dental procedures; * current participation in any other oral/dental product studies; * pregnancy or lactation; * diabetes, autoimmune or infectious diseases, dry mouth, skin diseases; * orthodontic appliances

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging

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