New drug aims to free MDS patients from frequent blood transfusions
NCT ID NCT05490446
Summary
This study is testing an investigational drug called AG-946 (tebapivat) for adults with a lower-risk form of myelodysplastic syndromes (MDS), a bone marrow disorder that causes anemia. The main goal is to see if the drug can help patients become independent from regular blood transfusions by improving their body's ability to make healthy red blood cells. Researchers will measure how many participants can go at least 8 weeks without a transfusion and monitor the drug's safety.
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Contacts and locations
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Locations
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Aberdeen Royal Infirmary - PPDS
Aberdeen, Aberdeen City, AB25 2ZN, United Kingdom
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Asan Medical Center - PPDS
Seoul, 05505, South Korea
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Attikon University General Hospital
Athens, Greece
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Azienda Ospedaliera Ordine Mauriziano di Torino
Turin, Piedmont, Italy
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C.H. Regional Reina Sofia - PPDS
Córdoba, 14004, Spain
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CHRU Lille
Lille, 59037, France
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CHU Angers
Angers, Maine-et-Loire, 49933, France
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Churchill Hospital-NHS Oxford
Oxford, OX3 7LE, United Kingdom
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Complejo Asistencial Universitario de Salamanca - H. Clinico
Salamanca, 37007, Spain
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David Geffen School of Medicine at UCLA
Los Angeles, California, 90024, United States
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Duke Adult Blood and Marrow Clinic
Durham, North Carolina, 27705, United States
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Edward H. Kaplan MD & Associates
Skokie, Illinois, 60076, United States
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Emad Ibrahim, MD, Inc.
Redlands, California, 92373, United States
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Fakultni nemocnice Ostrava
Ostrava, 708 52, Czechia
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Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
Milan, Lombardy, Italy
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Fondazione IRCCS Policlinico San Matteo di Pavia
Pavia, Lombardy, Italy
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Fondazione PTV Policlinico Tor Vergata
Roma, Italy
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Hippokration Hospital
Thessaloniki, Greece
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Hospital Universitario HM Sanchinarro - CIOCC
Madrid, 28050, Spain
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Hospital Universitario La Paz - PPDS
Madrid, 28046, Spain
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Hospital Universitario Virgen del Rocio - PPDS
Seville, 41013, Spain
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Hôpital Saint Louis
Paris, 75475, France
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Hôpital de La Conception
Marseille, Bouches-du-Rhône, 13010, France
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Innovative Clinical Research Institute Whittier
Lakewood, California, 90805, United States
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Istituto Clinico Humanitas
Rozzano, Lombardy, Italy
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Kings College Hospital
London, SE5 9RS, United Kingdom
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Kyungpook National University Hospital
Daegu, 41944, South Korea
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MTZ Clinical Research Powered by PRATIA - PPDS
Warsaw, Masovian Voivodeship, Poland
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Mayo Clinic Jacksonville - PPDS
Jacksonville, Florida, 32224, United States
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Medizinische Hochschule Hannover
Hanover, Lower Saxony, 30625, Germany
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Memorial Sloan Kettering Cancer Center
Long Island City, New York, 11101, United States
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Monash Health, Monash Medical Centre
Clayton, Victoria, 3168, Australia
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Ordensklinikum Linz GmbH Elisabethinen
Linz, Upper Austria, 4020, Austria
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Pratia Onkologia Katowice - PRATIA - PPDS
Katowice, Silesian Voivodeship, Poland
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SPZOZ MiSWiA z Warminsko-Mazurskim Centrum Onkologii w Olsztynie
Olsztyn, Warmian-Masurian Voivodeship, Poland
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Shaare Zedek Medical Center
Jerusalem, 9103102, Israel
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Smilow Cancer Hospital at Yale New Haven
New Haven, Connecticut, 06510, United States
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Tel Aviv Sourasky Medical Center PPDS
Tel Aviv, Israel
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The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, South Korea
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Universitatsklinikum Dusseldorf
Düsseldorf, North Rhine-Westphalia, 40225, Germany
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Universitatsklinikum Leipzig
Leipzig, Saxony, 04103, Germany
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University General Hospital of Patras
Pátrai, Greece
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University Hospital of Alexandroupolis
Alexandroupoli, Greece
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Western General Hospital Edinburgh - PPDS
Edinburgh, EH24 2XU, United Kingdom
Conditions
Explore the condition pages connected to this study.