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One hard workout may shift proteins tied to aging and brain health

NCT ID NCT07800156

Knowledge-focused Sponsor: Cemre Didem Eyipinar Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

Researchers are testing whether one intense aerobic exercise session, done until exhaustion, alters levels of four proteins in saliva: irisin, klotho, sirtuin-1, and BDNF. These proteins are linked to metabolism, aging, and brain function. The study enrolls healthy adults aged 18 to 45 who have no chronic disease. Participants provide saliva samples before and after exercise to measure any changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Aerobic exercise performed until exhaustion
What this could lead to
If it works, this could clarify how exercise affects key proteins linked to aging and brain health, possibly guiding future fitness or therapy recommendations.
What could go wrong
This is a small, early study with only 26 participants, so results may not apply broadly. It measures short-term biomarker changes, not long-term health outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 26 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Being between the ages of 18 and 45 * Being in good health and having no diagnosis of any chronic disease * Not having taken regular medication within the last 4 weeks * Voluntary participation and providing written informed consent Exclusion Criteria: * Individuals with a history of cardiovascular, endocrine, metabolic, or renal disease * Individuals with a history of active infection, musculoskeletal injury, or severe disability * Individuals with any medical condition that might prevent participation in exercise * Individuals unable to regularly participate in the exercise protocol throughout the study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Athlete Healthy adult

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Gaziantep University Faculty of Sports Sciences

    Gaziantep, Sehitkamil, 85142, Turkey (Türkiye)

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