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New shot aims to save sight in advanced macular degeneration

NCT ID NCT06990269

Disease control Sponsor: ADARx Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 3 times

Summary

This study tests an experimental drug called ADX-038 in 240 people with geographic atrophy, a form of advanced age-related macular degeneration that causes blind spots. The drug is given as a shot under the skin and is compared to a placebo to see if it can slow the loss of a key layer in the retina. Participants must have a certain size of retinal damage and be willing to get required vaccinations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 240 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Aug 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical diagnosis of GA of the macula secondary to AMD * GA lesions between 2.5 and 12.5 mm2 at screening * Sufficiently clear ocular media, adequate pupillary dilation and fixation to permit quality fundus imaging in the study eye as described in the protocol * Willing and able to comply with clinic visits and study-related procedures, including completion of the full series of meningococcal vaccinations and pneumococcal vaccination required per protocol Exclusion Criteria: * Has GA secondary to causes other than AMD * Has active ocular disease that compromises or confounds visual function * History of surgery for retinal detachment * Has ocular condition other than GA secondary to AMD * Use of intravitreal complement inhibitors in study eye * Hereditary or acquired complement deficiency * Active viral, bacterial or fungal infection * Liver injury as evidenced by abnormal liver function tests * Donating blood * History of choroidal neovascularization in the study eye

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration dry age related macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Geographic atrophy secondary to age-related macular degeneration

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    82 sites in 12 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • ADARx Clinical Site

    RECRUITING

    Gilbert, Arizona, 85297, United States

  • ADARx Clinical Site

    RECRUITING

    Phoenix, Arizona, 85020, United States

  • ADARx Clinical Site

    RECRUITING

    Bakersfield, California, 93309, United States

  • ADARx Clinical Site

    RECRUITING

    Beverly Hills, California, 90211, United States

  • ADARx Clinical Site

    RECRUITING

    Huntington Beach, California, 93647, United States

  • ADARx Clinical Site

    RECRUITING

    Poway, California, 92064, United States

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Riverside, California, 92505, United States

  • ADARx Clinical Site

    RECRUITING

    Walnut Creek, California, 94598, United States

  • ADARx Clinical Site

    RECRUITING

    Orlando, Florida, 32806, United States

  • ADARx Clinical Site

    RECRUITING

    Wildwood, Florida, 34785, United States

  • ADARx Clinical Site

    RECRUITING

    Hagerstown, Maryland, 21740, United States

  • ADARx Clinical Site

    RECRUITING

    Reno, Nevada, 89502, United States

  • ADARx Clinical Site

    WITHDRAWN

    Erie, Pennsylvania, 16505, United States

  • ADARx Clinical Site

    RECRUITING

    Austin, Texas, 78705, United States

  • ADARx Clinical Site

    RECRUITING

    Bellaire, Texas, 77401, United States

  • ADARx Clinical Site

    RECRUITING

    Dallas, Texas, 75231, United States

  • ADARx Clinical Site

    RECRUITING

    McAllen, Texas, 78503, United States

  • ADARx Clinical Site

    RECRUITING

    Round Rock, Texas, 78681, United States

  • ADARx Clinical Site

    RECRUITING

    San Antonio, Texas, 78340, United States

  • ADARx Clinical Site

    RECRUITING

    The Woodlands, Texas, 77384, United States

  • ADARx Clinical Site

    RECRUITING

    St. George, Utah, 84790, United States

  • ADARx Clinical Site

    RECRUITING

    Albury, New South Wales, 2640, Australia

  • ADARx Clinical Site

    RECRUITING

    Hurstville, New South Wales, 2220, Australia

  • ADARx Clinical Site

    RECRUITING

    Parramatta, New South Wales, 2150, Australia

  • ADARx Clinical Site

    RECRUITING

    Sutherland, New South Wales, 2232, Australia

  • ADARx Clinical Site

    RECRUITING

    Sydney, New South Wales, 2000, Australia

  • ADARx Clinical Site

    RECRUITING

    East Melbourne, Victoria, 3002, Australia

  • ADARx Clinical Site

    RECRUITING

    Rowville, Victoria, 3178, Australia

  • ADARx Clinical Site

    RECRUITING

    Malvern, VIC 3144, Australia

  • ADARx Clinical Site

    RECRUITING

    Sydney, NWS 2000, Australia

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Graz, Styria, 8036, Austria

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Innsbruck, Tyrol, 6020, Austria

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Vienna, 1090, Austria

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Vienna, 1140, Austria

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Edmonton, Alberta, T5H 0X5, Canada

  • ADARx Clinical Site

    RECRUITING

    Vancouver, British Columbia, V5Z 1M9, Canada

  • ADARx Clinical Site

    RECRUITING

    Vancouver, British Columbia, Canada

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    London, Ontario, N6A4V2, Canada

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Ottawa, Ontario, K1H 8L6, Canada

  • ADARx Clinical Site

    RECRUITING

    Ottawa, Ontario, K2B 7E9, Canada

  • ADARx Clinical Site

    RECRUITING

    Toronto, Ontario, M3C 0G9, Canada

  • ADARx Clinical Site

    RECRUITING

    Toronto, Ontario, M8X 2X3, Canada

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Prague, 100 34, Czechia

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Prague, 140 00, Czechia

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Praha Klanovice, 12808, Czechia

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Bonn, North Rhine-Westphalia, 53127, Germany

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Sulzbach, Saarland, 66280, Germany

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Cologne, 50937, Germany

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Giessen, 35392, Germany

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Mainz, 55122, Germany

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    München, 80336, Germany

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Münster, 48149, Germany

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Tübingen, 72076, Germany

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Pécs, Baranya, 7621, Hungary

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Budapest, 1085, Hungary

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Budapest, 1106, Hungary

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Budapest, 1133, Hungary

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Debrecen, 4032, Hungary

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Milan, MI, 20132, Italy

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Roma, RM, 00168, Italy

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Milan, 20121, Italy

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Milan, 20122, Italy

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Milan, 20142, Italy

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Novara, 28100, Italy

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Padova, 35128, Italy

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Coimbra, 3000-548, Portugal

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Coimbra, 3004-561, Portugal

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Coimbra, 3030-163, Portugal

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Porto, 4200-319, Portugal

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Barcelona, 08022, Spain

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Barcelona, 08035, Spain

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Barcelona, 08908, Spain

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Madrid, 28040, Spain

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Valencia, 46004, Spain

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Olten, Canton of Solothurn, 4600, Switzerland

  • ADARx Clinical Site

    RECRUITING

    Basel, 4031, Switzerland

  • ADARx Clinical Site

    RECRUITING

    Bern, 3010, Switzerland

  • ADARx Clinical Site

    RECRUITING

    Liverpool, BC, L7 8XP, United Kingdom

  • ADARx Clinical Site

    NOT_YET_RECRUITING

    Dorchester, Dorset, DT1 2JY, United Kingdom

  • ADARx Clinical Site

    RECRUITING

    Wolverhampton, West Midlands, WV10 0QP, United Kingdom

  • ADARx Clinical Site

    RECRUITING

    London, NW10 7NS, United Kingdom

  • ADARx Clinical Site

    RECRUITING

    London, SW17 0QT, United Kingdom

  • ADARx Clinical Site

    RECRUITING

    Sunderland, SR1 3AE, United Kingdom

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