New hope for advanced prostate cancer: experimental drug cocktails enter human testing
NCT ID NCT07198633
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests several new drug combinations for men with advanced prostate cancer that has spread. The experimental drugs include QLC5508 (a targeted therapy that delivers a toxin to cancer cells) and QLH12016 (a drug that breaks down the male hormone receptor). These are combined with standard hormone therapies. The trial has two phases: first, finding the safest dose, and then checking if the combinations shrink tumors or lower PSA levels. About 212 men will take part across multiple centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- QLC5508 (a targeted antibody-drug conjugate) and QLH12016 (an oral drug that degrades the androgen receptor), combined with standard hormone therapies abiraterone or enzalutamide
- What this could lead to
- If successful, this could point toward more effective combination treatments for advanced prostate cancer that has stopped responding to standard hormone therapy.
- What could go wrong
- This is an early-phase trial (Phase 1b/2) with a small number of participants, so the main goals are safety and dosing—not yet proof of effectiveness. Side effects from the new drug combinations are unknown, and many early-stage cancer trials do not lead to approved treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADVANCED PROSTATE CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Tianjin Medical University Cancer Institute & Hospital
RECRUITINGTianjin, Tianjin Municipality, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new injection tame prostate cancer by cutting testosterone?
- Can a new drug combo slow advanced prostate cancer?
- Smart missile drug takes aim at Hard-to-Treat prostate cancer
- Targeted radiation plus hormone therapy may slow Low-Volume prostate cancer spread
- New hope for advanced prostate cancer: experimental drug GDC-1261 enters trials
- New telehealth program aims to ease daily struggles for advanced cancer patients