New hope for rare cancer: drug combo targets tumor growth
NCT ID NCT05712694
First seen Apr 22, 2026 · Last updated May 09, 2026 · Updated 2 times
Summary
This phase 3 trial tests whether adding ADI-PEG 20 to standard chemotherapy (gemcitabine and docetaxel) helps control advanced leiomyosarcoma, a rare soft tissue cancer. About 300 adults whose cancer has worsened after prior treatment will receive either the study drug or a placebo alongside chemo. The main goal is to see if the combination slows tumor growth better than chemo alone.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
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Locations
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Chang Gung Medical Foundation Kaohsiung
RECRUITINGKaohsiung City, Niaosong District, 83301, Taiwan
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Columbia University
NOT_YET_RECRUITINGNew York, New York, 10032, United States
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Duke Cancer Institute
RECRUITINGDurham, North Carolina, 27710, United States
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Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
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Mass General Brigham Cancer Center
RECRUITINGBoston, Massachusetts, 02114, United States
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Mayo Clinic Arizona
RECRUITINGPhoenix, Arizona, 85054, United States
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Mayo Clinic Florida
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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McGill University Health Centre (Quebec)
RECRUITINGMontreal, Quebec, H4A 311, Canada
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Medical College of Wisconsin/ Froedtert Hospital
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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National Taiwan University Hospital
RECRUITINGTaipei, Taipei, 10002, Taiwan
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Northwestern
RECRUITINGChicago, Illinois, 60611, United States
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Ohio State University Wexner Medical Center/ The James Cancer Hospital and Solove Research Institute
RECRUITINGColumbus, Ohio, 43210, United States
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Stanford University Medical Centre
RECRUITINGPalo Alto, California, 94304, United States
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Taipei Veterans General Hospital
RECRUITINGTaipei, Taipei, 11217, Taiwan
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UCLA
RECRUITINGSanta Monica, California, 90404, United States
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UCSF
RECRUITINGSan Francisco, California, 94158, United States
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UHN - Princess Margaret Cancer Center (Ontario)
RECRUITINGToronto, Ontario, M5G 2M9, Canada
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UPMC Hillman Cancer Center
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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UPenn (Abramson Cancer Center, Pennsylvania Hospital)
RECRUITINGPhiladelphia, Pennsylvania, 19106, United States
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USC Norris comprehensive cancer center
RECRUITINGLos Angeles, California, 90033, United States
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University Hospitals Cleveland Medical Center
RECRUITINGCleveland, Ohio, 44106, United States
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University of Colorado Cancer Center/ CU Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045, United States
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University of Iowa
ACTIVE_NOT_RECRUITINGIowa City, Iowa, 52242, United States
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University of Miami/ Sylvester Comprehensive Cancer Center
RECRUITINGMiami, Florida, 33136, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Washington University School of Medicine - Siteman Cancer Center
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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