New drug cocktail targets Hard-to-Treat lung cancer mutation

NCT ID NCT05609578

Ongoing Disease control Sponsor: Mirati Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether combining the targeted drug adagrasib with immunotherapy (pembrolizumab) and chemotherapy can shrink tumors or delay progression in people with advanced non-small cell lung cancer that has a specific KRAS G12C mutation. The study enrolls adults whose cancer has not been treated before and whose tumors show at least some PD-L1 protein. Researchers will measure how many patients respond and how long the benefit lasts, while monitoring side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Adagrasib

What this could lead to

If successful, this combination could offer a new first-line treatment option for people with a specific genetic subtype of advanced lung cancer.

What could go wrong

This is an early-phase trial with a small number of participants. The drug combination may cause significant side effects, and results may not lead to a widely approved therapy.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

lung neoplasm metastatic malignant neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED NSCLC METASTATIC LUNG CANCER

Contacts and locations

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Locations

Local Institution - 017-080

Babylon, New York, 11702, United States
Local Institution - 017-081

Port Jefferson Station, New York, 11776, United States
Local Institution - 017-082

Patchogue, New York, 11772, United States
Local Institution - 017-083

The Bronx, New York, 10469, United States
Local Institution - 017-084

Riverhead, New York, 11901, United States
Local Institution - 017-085

New York, New York, 10028, United States
Local Institution - 017-086

Port Jefferson, New York, 11776, United States
Local Institution - 017-087

New Hyde Park, New York, 11042, United States
Local Institution - 017-088

Brooklyn, New York, 11210, United States
Local Institution - 017-190

Créteil, 94000, France
Local Institution - 017-192

Dijon, 21079, France
Local Institution - 017-196

Caen, 14076, France
Local Institution - 017-199

Marseille, 13009, France
Local Institution - 017-202

Villejuif, 94805, France
Local Institution - 017-234

Piraeus, 185 47, Greece
Local Institution - 017-235

Larissa, 41110, Greece
Local Institution - 017-238

Heraklion, 71110, Greece
Local Institution - 017-240

Törökbálint, 2045, Hungary
Local Institution - 017-241

Budapest, 1122, Hungary
Local Institution - 017-244

Budapest, 1121, Hungary
Local Institution - 017-278

Milan, 20141, Italy
Local Institution - 017-292

Avellino, 83100, Italy
Local Institution - 017-295

Roma, 00144, Italy
Local Institution - 017-382

Poznan, 60-639, Poland
Local Institution - 017-388

Boston, Massachusetts, 02215, United States
Local Institution - 017-535

Port Jefferson Station, New York, 11776, United States
Local Institution - 017-540

San Francisco, California, 94158, United States
Local Institution - 017-587

East Syracuse, New York, 13057, United States
Local Institution - 017-602

Palma de Mallorca, 07120, Spain
Local Institution - 017-603

Zaragoza, 50009, Spain
Local Institution - 017-613

A Coruña, 15006, Spain
Local Institution - 017-619

Madrid, 28007, Spain
Local Institution - 017-624

Madrid, 28046, Spain
Local Institution - 017-626

Majadahonda, 28222, Spain
Local Institution - 017-663

Toulouse, 31059, France
Local Institution - 017-667

Suresnes, 92150, France
Local Institution - 017-683

La Tronche, 38700, France
Local Institution - 017-686

Paris, 75020, France
Local Institution - 017-689

Angers, 49055, France
Local Institution - 017-757

Lodz, 90-302, Poland
Local Institution - 017-759

Székesfehérvár, 8000, Hungary
Local Institution - 017-762

Florence, 50134, Italy
Local Institution - 017-767

Ravenna, 48121, Italy
Local Institution - 017-771

Palma de Mallorca, 07198, Spain
Local Institution - 017-772

Seville, 41009, Spain
Local Institution - 017-773

Casale Monferrato, 15033, Italy
Local Institution - 017-774

Warsaw, 04-349, Poland
Local Institution - 017-788

Orbassano, 10043, Italy
Local Institution - 017-808

Boston, Massachusetts, 02215, United States
Local Institution - 017-811

Novi, Michigan, 48377, United States
Local Institution - 017-814

Fairfax, Virginia, 22031, United States
Local Institution - 017-814-A

Arlington, Virginia, 22205, United States
Local Institution - 017-814-B

Gainesville, Virginia, 20155, United States
Local Institution - 017-814-C

Reston, Virginia, 20190, United States
Local Institution - 017-818

Cleveland, Ohio, 44195, United States
Local Institution - 017-820

Westwood, Kansas, 66205, United States
Local Institution - 017-820A

Kansas City, Kansas, 66160, United States
Local Institution - 017-820B

Kansas City, Kansas, 66160, United States
Local Institution - 017-820C

Kansas City, Kansas, 66160, United States
Local Institution - 017-820D

Lee's Summit, Missouri, 64064, United States
Local Institution - 017-820E

Kansas City, Missouri, 64154, United States
Local Institution - 017-820F

Kansas City, Missouri, 64116, United States
Local Institution - 017-820G

North Kansas City, Missouri, 64116, United States
Local Institution - 017-820H

Kansas City, Kansas, 66160, United States
Local Institution - 017-820I

Overland Park, Kansas, 66210, United States
Local Institution - 017-820J

Fairway, Kansas, 66205, United States
Local Institution - 017-829

Jacksonville, Florida, 32224, United States
Local Institution - 017-830

Rochester, Minnesota, 55905, United States
Local Institution - 017-838

Saint Louis Park, Minnesota, 55416, United States
Local Institution - 017-838A

Saint Louis Park, Minnesota, 55426-5000, United States
Local Institution - 017-838B

Minneapolis, Minnesota, 55404, United States
Local Institution - 017-838C

Minneapolis, Minnesota, 55404, United States
Local Institution - 017-851

Fullerton, California, 92835, United States
Local Institution - 017-872

Lone Tree, Colorado, 80124, United States
Local Institution - 017-872-A

Lakewood, Colorado, 80228, United States
Local Institution - 017-872-B

Denver, Colorado, 80218, United States
Local Institution - 017-872-C

Littleton, Colorado, 80218, United States
Local Institution - 017-872-D

Colorado Springs, Colorado, 80907, United States
Local Institution - 017-872-E

Pueblo, Colorado, 81003, United States
Local Institution - 017-872-F

Denver, Colorado, 80220, United States
Local Institution - 017-872-G

Boulder, Colorado, 80303, United States
Local Institution - 017-872-H

Thornton, Colorado, 80260, United States
Local Institution - 017-872-I

Aurora, Colorado, 80012, United States
Local Institution - 017-872-J

Colorado Springs, Colorado, 80920, United States
Local Institution - 017-878

Longview, Texas, 75601, United States
Local Institution - 017-878-A

Tyler, Texas, 75702, United States
Local Institution - 017-878-B

Palestine, Texas, 75801, United States
Local Institution - 017-878-C

Paris, Texas, 75460, United States
Local Institution - 017-879

Dallas, Texas, 75246, United States
Local Institution - 017-898

Lakeland, Florida, 33812, United States
Local Institution - 017-909

Bellingham, Washington, 98225, United States
Local Institution - 017-936

Fountain Valley, California, 92708, United States
Local Institution - 017-936C

Fountain Valley, California, 92708, United States
Local Institution - 017-972

Chicago, Illinois, 60637, United States