New study tests skipping brain radiation when drugs work
NCT ID NCT06974370
First seen Jun 24, 2026 · Last updated Jun 24, 2026
Summary
This study is testing whether people with brain metastases from lung cancer or other solid tumors can safely avoid radiation therapy if their brain tumors shrink or stay stable with systemic treatments like immunotherapy, targeted therapy, or chemotherapy. Forty-five participants will be monitored with MRI scans every three months, and radiation will only be used if the tumors grow. The goal is to see if this approach is feasible and which patients might benefit most.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Vermont Medical Center
RECRUITINGBurlington, Vermont, 05401, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
systemic therapy (immunotherapy, targeted therapy, or chemotherapy)
What this could lead to
If successful, this could show that many patients with brain metastases can avoid radiation and its side effects by relying on systemic therapy and regular MRI scans.
What could go wrong
This is a small pilot study with only 45 participants, so results may not apply to everyone. Some patients may still need radiation if the cancer progresses.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.