New hope for rare bleeding disorder: which drug combo works best?

NCT ID NCT01808911

Completed Disease control Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two drug combinations in 110 adults with acquired hemophilia, a rare condition where the immune system attacks clotting factors, causing severe bleeding. One group received steroids plus cyclophosphamide, the other steroids plus rituximab. The goal was to see which approach better eliminates the harmful antibodies and restores normal clotting, while tracking side effects like infections and major bleeds.

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Conditions

The condition(s) this trial relates to.

acquired hemophilia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACQUIRED HAEMOPHILIA

Contacts and locations

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Locations

AP-HM, University Hospital La Conception

Marseille, 13385, France
Europen Hospital of Georges Pompidou (HEGP)

Paris, 75908, France
Hopsital Bretonneau

Tours, 37044, France
Hospital Ambroise Paré

Boulogne-Billancourt, 92104, France
Hospital Archet 1

Nice, 06202, France
Hospital Bichat

Paris, 75018, France
Hospital Cochin

Paris, 75679, France
Hospital Henri Mondor

Créteil, 94010, France
Hospital Jean Verdier

Bondy, 93140, France
Hospital Kremlin-Bicêtre

Le Kremlin-Bicêtre, 94270, France
Hospital Lyon Sud

Pierre-Bénite, 69495, France
Hospital Nord

Saint-Etienne, 42055, France
Hospital Pitié-Salpêtrière

Paris, 75651, France
Hospital Purpan

Toulouse, 31059, France
Hospital Rangueil

Toulouse, 31059, France
Hospital Saint-Louis

Paris, 75475, France
Hospital Sud / Hospital Pontchaillou

Rennes, 35000, France
Hospital of Béziers

Béziers, 34525, France
Regional Center of Haemophilia Treatment (CRTH) de Lorraine

Nancy, France
University Hospital Amiens

Amiens, 80054, France
University Hospital Bocage

Dijon, 21079, France
University Hospital Côte de Nacre

Caen, 14033, France
University Hospital G. Montpied

Clermont-Ferrand, 63003, France
University Hospital Michallon

Grenoble, 38043, France
University Hospital Saint-Eloi

Montpellier, 34295, France
University Hospital of Bordeaux - Hospital Haut-Lévêque

Pessac, 33604, France
University Hospital of Brest - Hospital La cavale Blanche

Brest, 29609, France
University Hospital of Dijon - Hospital Général

Dijon, 21033, France
University Hospital of Nantes, Hospital Hôtel-Dieu

Nantes, 44093, France
University Hospital of Poitiers

Poitiers, 86021, France
University Hospital of Rouen

Rouen, 76031, France
University Regional Hospital Hautepierre

Strasbourg, 67098, France
University Regional Hospital of Lille

Lille, 59037, France
university Hospital of Limoges

Limoges, 87042, France