New pill aims to quiet hallucinations in Alzheimer's patients

NCT ID NCT06159673

Recruiting now Symptom relief Sponsor: ACADIA Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This clinical trial tests a drug called ACP-204 to see if it can reduce hallucinations and delusions in people with Alzheimer's disease. The study will involve over 1,000 adults aged 55 to 95 who have Alzheimer's and psychosis. Participants will receive either ACP-204 or a placebo for 6 weeks, and researchers will track changes in their symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ACP-204 (a drug that blocks serotonin receptors in the brain)

What this could lead to

If successful, this could provide a new treatment option to reduce hallucinations and delusions in people with Alzheimer's disease, improving their quality of life.

What could go wrong

This is an early-to-mid-stage trial, so the drug may not prove effective or safe. Side effects are possible, and results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Delusions Hallucinations

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER'S DISEASE PSYCHOSIS

Contacts and locations

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Study contacts

Contact

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Contact

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Locations

ABBA Medical Group LLC
RECRUITING

Miami, Florida, 33176, United States
AOU Policlinico Umberto I
WITHDRAWN

Roma, 00185, Italy
ASST degli Spedali Civili di Brescia
ACTIVE_NOT_RECRUITING

Brescia, 25123, Italy
ATP Clinical Research
RECRUITING

Costa Mesa, California, 92626, United States
Abington Neurological Associates
RECRUITING

Abington, Pennsylvania, 19001, United States
Ad71 S.R.O.
ACTIVE_NOT_RECRUITING

Prague, Czech Republic, 109 00, Czechia
Advanced Clinical Research Network, Corp
RECRUITING

Miami, Florida, 33135, United States
Advanced Research Center, Inc.
WITHDRAWN

Anaheim, California, 92805, United States
Alivation Research, LLC
WITHDRAWN

Lincoln, Nebraska, 68526, United States
Arrow Clinical Trials
RECRUITING

Daytona Beach, Florida, 32117, United States
Azienda Ospedaliera Card. G. Panico
ACTIVE_NOT_RECRUITING

Tricase, 73039, Italy
Azienda Ospedaliera Universitaria OO. RR. S.
ACTIVE_NOT_RECRUITING

Salerno, 84131, Italy
B&B Investigaciones Medicas SC
RECRUITING

Mazatlán, Mexico, 82140, Mexico
BIND Investigaciones S.C.
RECRUITING

San Luis Potosí City, 78213, Mexico
BR Trials-Ensaios Clinicos e Consultoria
RECRUITING

São Paulo, 01236-030, Brazil
BRAIN-SOUL THERAPY s.r.o.
ACTIVE_NOT_RECRUITING

Kladno, Czech Republic, 27201, Czechia
Biomedica Research Group
RECRUITING

Santiago, 7500710, Chile
CECPAR Centro de Estudos Clinicos do Parana
RECRUITING

Curitiba, 80030-310, Brazil
CHRU de Tours- Hopital Bretonneau
ACTIVE_NOT_RECRUITING

Tours, 37044, France
CHU Rouen-Hospital Charles Nicolle
ACTIVE_NOT_RECRUITING

Rouen, 76031, France
CHU de Limoges-Hopital Dupuytren
ACTIVE_NOT_RECRUITING

Limoges, 87042, France
CIC de la Universidad Catolica CICUC
RECRUITING

Santiago, 8330024, Chile
CLINTRIAL s.r.o.
ACTIVE_NOT_RECRUITING

Prague, 100 00, Czechia
Central Miami Medical Institute
WITHDRAWN

Miami, Florida, 33125, United States
Centre Memoire Ressources Recherche CMRR
ACTIVE_NOT_RECRUITING

Dijon, 21000, France
Centre pour Personnes Âgées
WITHDRAWN

Colmar, 68000, France
Centro Estudios Clínicos y Esp. Médicas SC CECEM
RECRUITING

Nuevo León, 64620, Mexico
Centro para el Des de la Med y de Asist Med Esp SC
RECRUITING

Sinaloa, 80230, Mexico
Chandler Clinical Trials
RECRUITING

Chandler, Arizona, 85224, United States
Clinical Endpoint LLC
RECRUITING

Scottsdale, Arizona, 85258, United States
Clinical Hosp Center Dr Dragisa Misovic Dedinje
ACTIVE_NOT_RECRUITING

Belgrade, 11000, Serbia
Clinical Research Institute S.C
RECRUITING

Estado de México, 54055, Mexico
Clinical Trial Network LLC
RECRUITING

Houston, Texas, 77074, United States
Clinical. Hospital Center Zvezdara
ACTIVE_NOT_RECRUITING

Belgrade, 11000, Serbia
Combined Research Orlando Phase I IV
RECRUITING

Orlando, Florida, 32807, United States
DCC "Higia"
ACTIVE_NOT_RECRUITING

Pazardzhik, 4400, Bulgaria
DCC St. Vrach and St. St. Kuzma and Damian OOD
ACTIVE_NOT_RECRUITING

Sofia, 1408, Bulgaria
Dent Neurologic Institute
WITHDRAWN

Amherst, New York, 14226, United States
Dipartimento di Neuroscienze Rita Levi Montalcini
WITHDRAWN

Torino, 10126, Italy
E-DA Hospital
RECRUITING

Kaohsiung City, Taiwan
ET Dr. Ivo Natsov - AIPSMC in Psychiatry
ACTIVE_NOT_RECRUITING

Cherven Bryag, 5980, Bulgaria
Especialidades Medicas L y S
RECRUITING

Santiago, 7560356, Chile
Eunpyeong St. Mary's Hospital
TERMINATED

Seoul, Seoul, 03312, South Korea
FORBELI s.r.o.
WITHDRAWN

Prague, 160 00, Czechia
Facili-Centro Integrado de Psiquiatria
RECRUITING

São Bernardo do Campo, 09726-150, Brazil
Fakultni nemocnice u sv. Anny v Brne
ACTIVE_NOT_RECRUITING

Brno, 656 91, Czechia
Finger Lakes Clinical Research
WITHDRAWN

Rochester, New York, 14618, United States
First Excellent Research Group
RECRUITING

Doral, Florida, 33178, United States
Floridian Neuroscience Institutue
RECRUITING

Miami Lakes, Florida, 33016, United States
Fondazione Policlinico Uni Campus Bio-Medico di Roma
ACTIVE_NOT_RECRUITING

Roma, 00128, Italy
Future Care Solution, LLC
RECRUITING

Miami, Florida, 33165, United States
Gachon University Gil Medical Center
RECRUITING

Incheon, 21565, South Korea
Gen. Hosp. Dr Radivoj Simonovic
WITHDRAWN

Sombor, 25000, Serbia
General Hospital Valjevo
WITHDRAWN

Valjevo, 14000, Serbia
Grace Research, LLC
RECRUITING

Shreveport, Louisiana, 71105, United States
Hanyang University Seoul Hospital
TERMINATED

Seoul, 04763, South Korea
Health Pharma Professional Research S.A. de C.V.
RECRUITING

Mexico City, 03100, Mexico
Homestead Associates in Research Inc.
RECRUITING

Miami, Florida, 33032, United States
Hopital BROCA
ACTIVE_NOT_RECRUITING

Paris, 75013, France
Hopital Neurologique Bron
WITHDRAWN

Bron, 69677, France
Hopital Purpan
WITHDRAWN

Toulouse, 31059, France
Horizon Clinical Research Group
RECRUITING

Cypress, Texas, 77429, United States
Hospices Civils de Lyon HCL
WITHDRAWN

Lyon, 69002, France
Hospital Moinhos de Vento
RECRUITING

Porto Alegre, 90035-001, Brazil
Hospital Provincial de Zamora
ACTIVE_NOT_RECRUITING

Zamora, 49021, Spain
Hospital Sao Paulo
RECRUITING

São Paulo, 04024-002, Brazil
Hospital Universitario Dr. Gonzalo Valdes Valdes
RECRUITING

Coahuila, 25000, Mexico
Hospital Universitario Dr. Jose Eleuterio Gonzalez
RECRUITING

Monterrey, Nuevo León, 64460, Mexico
Hospital Universitario Virgen Macarena
ACTIVE_NOT_RECRUITING

Seville, 41009, Spain
Hospital Universitario de Brasilia
RECRUITING

Brasília, 70840-901, Brazil
Hospital das Clínicas da Faculdade de Medicina USP
WITHDRAWN

São Paulo, 05403-000, Brazil
Humanity Clinical Research Corp
RECRUITING

Aventura, Florida, 33180, United States
Hôpital La Grave
ACTIVE_NOT_RECRUITING

Toulouse, 31059, France
Hôpital Lariboisière
ACTIVE_NOT_RECRUITING

Paris, 75010, France
Hôpital de Brabois Adultes
ACTIVE_NOT_RECRUITING

Vandœuvre-lès-Nancy, 545000, France
INEP medical s.r.o
WITHDRAWN

Prague, 186 00, Czechia
IRCCS Neuromed Istituto Neurologico Mediterraneo
WITHDRAWN

Isernia, 86077, Italy
Iecsi S.C.
RECRUITING

Monterrey, N.L, 64310, Mexico
Inha University Hospital
RECRUITING

Incheon, 22332, South Korea
Insight Clinical Trials LLC
WITHDRAWN

Beachwood, Ohio, 44122, United States
Inst. de Neurologia de Curitiba Hospital Ecoville
RECRUITING

Curitiba, 81210-310, Brazil
Institute of Mental Health
ACTIVE_NOT_RECRUITING

Belgrade, 11000, Serbia
Instituto Mederi de Pesquisa e Saude
RECRUITING

Passo Fundo, 99010-120, Brazil
Janjic University Clinical Center Kragujevac
ACTIVE_NOT_RECRUITING

Kragujevac, 34000, Serbia
Jovanovic University Clinical Centre of Kragujevac
ACTIVE_NOT_RECRUITING

Kragujevac, 34000, Serbia
Kaleidoscope Clinical Research
RECRUITING

Houston, Texas, 77089, United States
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80756, Taiwan
Khan Revive Research Institute
WITHDRAWN

Rochester Hills, Michigan, 48307, United States
Konkuk University Medical Center
WITHDRAWN

Seoul, 05030, South Korea
Korea University Anam Hospital
RECRUITING

Seoul, 02841, South Korea
L2IP - Instituto de Pesquisas Clínicas Ltda
RECRUITING

Brasília, 70200-730, Brazil
MediClear Medical & Research Center, Inc.
RECRUITING

Miami, Florida, 33165, United States
Medical Center Hera EOOD
WITHDRAWN

Sofia, 1510, Bulgaria
Medical Center Intermediea
WITHDRAWN

Sofia, 1680, Bulgaria
Medical Center Lifemed
RECRUITING

Kardzhali, Bulgaria, 6600, Bulgaria
Medical center Medconsult Pleven OOD
ACTIVE_NOT_RECRUITING

Pleven, 5800, Bulgaria
Medical center Spectar-Plovdic EOOD
WITHDRAWN

Plovdiv, 4004, Bulgaria
Mental Health Centre - Prof. N Shipkovenski EOOD
ACTIVE_NOT_RECRUITING

Sofia, 1377, Bulgaria
Mexico Centre for Clinical Research S.A de C.V
RECRUITING

Mexico City, 03100, Mexico
NEUROHK s.r.o
ACTIVE_NOT_RECRUITING

Choceň, 56501, Czechia
National Cheng Kung University Hospital
WITHDRAWN

Tainan, 704, Taiwan
National Institute of Clinical Research
TERMINATED

Garden Grove, California, 92844, United States
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Neuro-Pain Medical Center
RECRUITING

Fresno, California, 93710, United States
Neurociencias Estudios Clinicos
RECRUITING

Sinaloa, 80020, Mexico
Neurologia-Fondazione Instituto G. Giglio
ACTIVE_NOT_RECRUITING

Cefalù, 90015, Italy
Neuroscience Research Institute
RECRUITING

West Palm Beach, Florida, 33407, United States
New Life Medical Research Center Inc.
RECRUITING

Hialeah, Florida, 33012, United States
New Med Research
RECRUITING

Miami Gardens, Florida, 33056, United States
Nucleo de Pesquisa Clínica do Rio Grande do Sul
WITHDRAWN

Porto Alegre, 90430-001, Brazil
Ospedale San Raffaele
WITHDRAWN

Milan, 20132, Italy
Policlinico Universitario Agostino Gemelli
ACTIVE_NOT_RECRUITING

Roma, 00168, Italy
Premier Clinical Research Institute, Inc.
RECRUITING

Miami, Florida, 33122, United States
Prolato Clinical Research Center-Patton
RECRUITING

Houston, Texas, 77054, United States
Psicomed Estudios Medicos
RECRUITING

Antofagasta, 1270244, Chile
Psych Me Medical Research Inc
WITHDRAWN

Tampa, Florida, 33614, United States
Quantum Clinical Trials
RECRUITING

Miami Beach, Florida, 33140, United States
R & H Clinical Research Inc.
WITHDRAWN

Stafford, Texas, 77477, United States
Regional Neurological Associates
WITHDRAWN

The Bronx, New York, 10466, United States
Reliable Clinical Research LLC.
RECRUITING

Hialeah, Florida, 33012, United States
Revive Research Institute, Inc.
WITHDRAWN

Elgin, Illinois, 60123, United States
Ruschel Medicina e Pesquisa Clínica
RECRUITING

Rio de Janeiro, 22270-060, Brazil
SMG-SNU Boramae Medical Center
RECRUITING

Seoul, 07061, South Korea
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Santa Paula Hospital Clinical Research Center
RECRUITING

São Paulo, 04550-000, Brazil
Special Hospital for Cerebrovascular Disease Sveti Sava
ACTIVE_NOT_RECRUITING

Belgrade, 11000, Serbia
Special Hospital for Psychiatric Diseases
ACTIVE_NOT_RECRUITING

Gornja Toponica, 18202, Serbia
Spl. Hosp. for Psychiatric Diseases Kovin
TERMINATED

Kovin, 26220, Serbia
Spl. Hosp. for Psychiatric Diseases Sveti Vracevi
WITHDRAWN

Novi Kneževac, 23330, Serbia
Steven South Goldstein MD and Associates
RECRUITING

Houston, Texas, 77089, United States
Taipei Medical University-Shuang Ho Hospital
WITHDRAWN

New Taipei City, 23561, Taiwan
Tranquil Clinical Research
WITHDRAWN

Webster, Texas, 77598, United States
TrialTech Tecnologia com Pesquisas em Medicamentos
RECRUITING

Curitiba, 80240-280, Brazil
UMHAT "Alexandrovska" EAD
ACTIVE_NOT_RECRUITING

Sofia, 1431, Bulgaria
UMHAT Alexandrovska EAD
ACTIVE_NOT_RECRUITING

Sofia, 1431, Bulgaria
UMHAT Prof. Dr. St. Kirkovich AD
WITHDRAWN

Stara Zagora, 6003, Bulgaria
UMHAT Sv. Georgi EAD
ACTIVE_NOT_RECRUITING

Plovdiv, 4000, Bulgaria
University Clinical Center Kragujevac
ACTIVE_NOT_RECRUITING

Kragujevac, 34000, Serbia
University Clinical Center Nis
ACTIVE_NOT_RECRUITING

Niš, 18000, Serbia
University of Texas Health Science Center
TERMINATED

Houston, Texas, 77054, United States
Valley Medical Research
WITHDRAWN

Centerville, Ohio, 45459, United States
Verus Clinical Research
RECRUITING

Miami, Florida, 33135, United States
Vestra Clinics s.r.o.
ACTIVE_NOT_RECRUITING

Rychnov nad Kněžnou, 516 01, Czechia
Visionary Investigators Network
WITHDRAWN

Miami, Florida, 33176, United States
World Research Link
RECRUITING

Pasadena, Texas, 77504, United States