New pill combo aims to boost lymphoma cure rates

NCT ID NCT04002947

First seen Nov 01, 2025 · Last updated Apr 26, 2026 · Updated 18 times

Summary

This study tests whether adding the drug acalabrutinib to standard chemotherapy can cure more people with untreated aggressive B-cell lymphoma. About 132 adults will take the pill twice daily for up to 14 days, then receive standard chemo and rituximab over six 21-day cycles. The goal is to see if this combination increases the number of patients whose cancer disappears or shrinks significantly.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.