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New hope for elderly lymphoma patients: chemo-free combo shows promise

NCT ID NCT05952024

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 23 times

Summary

This study tests a combination of two drugs, acalabrutinib and rituximab, in patients aged 80+ or 65-79 who are too frail for standard chemotherapy. The goal is to see if this gentler approach is safe and effective for treating diffuse large B-cell lymphoma. About 80 participants will receive the treatment and be monitored for side effects and cancer response.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Research Site

    WITHDRAWN

    Berkeley, California, 94704, United States

  • Research Site

    COMPLETED

    La Jolla, California, 92093, United States

  • Research Site

    RECRUITING

    Orange, California, 92868, United States

  • Research Site

    WITHDRAWN

    Stamford, Connecticut, 06902, United States

  • Research Site

    ACTIVE_NOT_RECRUITING

    Jacksonville, Florida, 32256, United States

  • Research Site

    RECRUITING

    Des Moines, Iowa, 50309, United States

  • Research Site

    WITHDRAWN

    Lexington, Kentucky, 40536, United States

  • Research Site

    ACTIVE_NOT_RECRUITING

    Beltsville, Maryland, 20705, United States

  • Research Site

    ACTIVE_NOT_RECRUITING

    Towson, Maryland, 21204, United States

  • Research Site

    ACTIVE_NOT_RECRUITING

    Detroit, Michigan, 48202, United States

  • Research Site

    WITHDRAWN

    Sioux Falls, South Dakota, 57104, United States

  • Research Site

    ACTIVE_NOT_RECRUITING

    Lubbock, Texas, 79410, United States

  • Research Site

    ACTIVE_NOT_RECRUITING

    Olympia, Washington, 98506, United States

  • Research Site

    RECRUITING

    Tacoma, Washington, 98405, United States

  • Research Site

    ACTIVE_NOT_RECRUITING

    Barretos, 14784-400, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Belo Horizonte, 30150-221, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Brasília, 70200-730, Brazil

  • Research Site

    RECRUITING

    Brasília, 70390-700, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Brasília, 70840-901, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Campinas, 13060-803, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Curitiba, 81520-060, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Florianópolis, 88020-210, Brazil

  • Research Site

    RECRUITING

    Florianópolis, 88034-000, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Goiânia, 74605-020, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Natal, 59075-740, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Porto Alegre, 90035-003, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Porto Alegre, 90880-480, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Recife, 50070-480, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Ribeirão Preto, 14048-900, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Rio de Janeiro, 20231-050, Brazil

  • Research Site

    RECRUITING

    São José do Rio Preto, 15090-000, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    São Luís, 65060-645, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    São Paulo, 01229-010, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    São Paulo, 01409-02, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    São Paulo, 05652-900, Brazil

  • Research Site

    COMPLETED

    São Paulo, 08270-070, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    São Paulo, 1323000, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    Sorocaba, 18030-005, Brazil

  • Research Site

    ACTIVE_NOT_RECRUITING

    San Juan, 00917, Puerto Rico

  • Research Site

    RECRUITING

    Busan, 47392, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Busan, 49241, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Daegu, 42601, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Gyeongsangnam-do, 52727, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Incheon, 405-760, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Jeonju, 54907, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Seogu, 49201, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Seoul, 03722, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Seoul, 05505, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Seoul, 06351, South Korea

  • Research Site

    RECRUITING

    Seoul, 06591, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Seoul, 07985, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Suwon, 16499, South Korea

  • Research Site

    ACTIVE_NOT_RECRUITING

    Ulsan, 44033, South Korea

  • Research Site

    WITHDRAWN

    Kaohsiung City, 80756, Taiwan

  • Research Site

    WITHDRAWN

    Kaohsiung City, 833, Taiwan

  • Research Site

    WITHDRAWN

    Tainan, 736, Taiwan

  • Research Site

    WITHDRAWN

    Taipei, 100, Taiwan

Conditions

Explore the condition pages connected to this study.

DIFFUSE LARGE B-CELL LYMPHOMA