New pill AC-003 tested for severe transplant complication
NCT ID NCT07070674
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing an experimental drug called AC-003 in 24 adults who have acute graft-versus-host disease (aGVHD) after a stem cell transplant and whose condition has not improved with steroids. The study aims to see if the drug is safe and tolerable, and to get an early look at whether it might help control the disease. Participants will take AC-003 capsules by mouth, and researchers will monitor side effects and any signs of improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AC-003 capsules
- What this could lead to
- If successful, this could point toward a new treatment option for patients with acute graft-versus-host disease that does not respond to steroids.
- What could go wrong
- This is a very early, small Phase Ib trial with only 24 participants, so results may not confirm safety or effectiveness. The drug may cause side effects or fail to improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hematology Hospital of Chinese Academy of Medical Sciences (Institute of Hematology, Chinese Academy of Medical Sciences)
RECRUITINGTianjin, Tianjin Municipality, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Combination drug approach aims to tame immune attack after stem cell transplant
- New shot may shield transplant patients from deadly immune attack
- New drug shows promise in controlling transplant complications
- Poop pills may tame deadly transplant complication
- JAKAVI under the microscope: new study tracks GVHD treatment in real life