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New hope for tough depression: experimental pill shows promise in clinical trial

NCT ID NCT06633016

Recruiting now Symptom relief Sponsor: Autobahn Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 06, 2026 · Updated 26 times

Summary

This study tests whether adding a new drug called ABX-002 to standard antidepressants can help adults with moderate to severe major depression who haven't gotten enough relief from their current medication. About 230 participants will receive either ABX-002 or a placebo for 6 weeks, and researchers will measure changes in depression symptoms using standard rating scales. The goal is to see if ABX-002 can safely improve mood and daily functioning.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Autobahn Site #101

    RECRUITING

    Jacksonville, Florida, 32256, United States

  • Autobahn Site #102

    ACTIVE_NOT_RECRUITING

    Orlando, Florida, 32822, United States

  • Autobahn Site #104

    RECRUITING

    Staten Island, New York, 10314, United States

  • Autobahn Site #105

    RECRUITING

    Brooklyn, New York, 11229, United States

  • Autobahn Site #106

    ACTIVE_NOT_RECRUITING

    Oceanside, California, 92056, United States

  • Autobahn Site #107

    RECRUITING

    Oklahoma City, Oklahoma, 73112, United States

  • Autobahn Site #108

    RECRUITING

    Brandon, Florida, 33511, United States

  • Autobahn Site #109

    RECRUITING

    Beachwood, Ohio, 44122, United States

  • Autobahn Site #110

    RECRUITING

    Hialeah, Florida, 33012, United States

  • Autobahn Site #111

    RECRUITING

    Miami, Florida, 33144, United States

  • Autobahn Site #112

    RECRUITING

    Decatur, Georgia, 30030, United States

  • Autobahn Site #113

    WITHDRAWN

    Encino, California, 91316, United States

  • Autobahn Site #116

    ACTIVE_NOT_RECRUITING

    Phoenix, Arizona, 85102, United States

  • Autobahn Site #117

    WITHDRAWN

    Newport Beach, California, 92660, United States

  • Autobahn Site #119

    RECRUITING

    San Jose, California, 95124, United States

  • Autobahn Site #120

    ACTIVE_NOT_RECRUITING

    Savannah, Georgia, 31405, United States

  • Autobahn Site #121

    WITHDRAWN

    Los Alamitos, California, 90720, United States

  • Autobahn Site #122

    RECRUITING

    Cromwell, Connecticut, 06416, United States

  • Autobahn Site #123

    ACTIVE_NOT_RECRUITING

    Atlanta, Georgia, 30328, United States

  • Autobahn Site #124

    RECRUITING

    Glendale, California, 91206, United States

  • Autobahn Site #125

    ACTIVE_NOT_RECRUITING

    New York, New York, 10022, United States

  • Autobahn Site #126

    RECRUITING

    Walnut Creek, California, 94596, United States

  • Autobahn Site #127

    RECRUITING

    Saint Charles, Missouri, 63304, United States

  • Autobahn Site #128

    ACTIVE_NOT_RECRUITING

    North Charleston, South Carolina, 29405, United States

  • Autobahn Site #129

    RECRUITING

    Berlin, New Jersey, 08009, United States

  • Autobahn Site #130

    WITHDRAWN

    Las Vegas, Nevada, 89121, United States

  • Autobahn Site #131

    RECRUITING

    Birmingham, Alabama, 35294, United States

  • Autobahn Site #132

    ACTIVE_NOT_RECRUITING

    Chandler, Arizona, 85224, United States

  • Autobahn Site #133

    WITHDRAWN

    Encino, California, 91316, United States

  • Autobahn Site #134

    RECRUITING

    Brooklyn, New York, 11235, United States

  • Autobahn Site #136

    WITHDRAWN

    Tucson, Arizona, 85704, United States

  • Autobahn Site #137

    RECRUITING

    Boston, Massachusetts, 02130, United States

  • Autobahn Site #138

    ACTIVE_NOT_RECRUITING

    Watertown, Massachusetts, 02472, United States

  • Autobahn Site #139

    ACTIVE_NOT_RECRUITING

    Lake City, Florida, 32055, United States

  • Autobahn Site #140

    RECRUITING

    Long Beach, California, 90807, United States

  • Autobahn Site #141

    ACTIVE_NOT_RECRUITING

    Miami, Florida, 33157, United States

  • Autobahn Site #142

    RECRUITING

    Peachtree Corners, Georgia, 30071, United States

  • Autobahn Site #143

    RECRUITING

    Bellevue, Washington, 98007, United States

  • Autobahn Site #144

    RECRUITING

    Sherman, Texas, 75092, United States

  • Autobahn Site #145

    RECRUITING

    Fairfax, Virginia, 22030, United States

  • Autobahn Site #146

    RECRUITING

    San Antonio, Texas, 78215, United States

  • Autobahn Site #147

    RECRUITING

    Miami Gardens, Florida, 33014, United States

  • Autobahn Site #148

    RECRUITING

    Tampa, Florida, 33629, United States

  • Autobahn Site #149

    RECRUITING

    West Covina, California, 91790, United States

  • Autobahn Site #150

    RECRUITING

    Anaheim, California, 92805, United States

  • Autobahn Site #151

    RECRUITING

    Rancho Cucamonga, California, 91730, United States

  • Autobahn Site #152

    RECRUITING

    Orange, California, 92866, United States

  • Autobahn Site #153

    RECRUITING

    Beaumont, Texas, 77701, United States

  • Autobahn Site #154

    ACTIVE_NOT_RECRUITING

    Elgin, Illinois, 60123, United States

  • Autobahn Site #159

    RECRUITING

    Orem, Utah, 84058, United States

Conditions

Explore the condition pages connected to this study.

MAJOR DEPRESSIVE DISORDER