Which folate supplement works best for Moms-to-Be?

NCT ID NCT06935630

Completed Disease control Sponsor: Dr. Soetomo General Hospital Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study compares two forms of folate—5-MTHF and folic acid—to see which one better increases red blood cell folate levels in pregnant women. Healthy pregnant women aged 25-35 with a gestational age of 9-14 weeks are randomly assigned to take one of the two supplements daily for three months. The main goal is to measure changes in folate levels and determine if 5-MTHF leads to higher levels than folic acid, which could inform future prenatal care guidelines.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 5-methyltetrahydrofolate (5-MTHF) and folic acid
What this could lead to: If 5-MTHF proves more effective, it could lead to updated prenatal supplement recommendations, potentially improving folate status and reducing neural tube defect risks in pregnancies.
What could go wrong: This is a small, early-phase trial with 96 participants, so results may not apply broadly. The study measures blood folate levels, not actual health outcomes, so real-world benefits remain uncertain.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PREGNANT WOMEN

Contacts and locations

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Locations

Mulyorejo Public Health

Surabaya, East Java, 60114, Indonesia

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