One shot to save sight? gene therapy trial aims to end frequent eye injections for wet AMD

NCT ID NCT07064759

Recruiting now Disease control Sponsor: 4D Molecular Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests a single injection of 4D-150, a gene therapy, in 480 adults with wet age-related macular degeneration (AMD). The goal is to see if one treatment can maintain or improve vision and reduce the need for standard anti-VEGF injections like Eylea. Participants will be followed for up to two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 4D-150 (a gene therapy given as a single eye injection)
What this could lead to: If successful, this could mean people with wet AMD need far fewer eye injections, possibly just one treatment lasting years instead of regular shots.
What could go wrong: This is still an early Phase 3 trial, so results are not guaranteed. The gene therapy may not work for everyone, and there could be side effects like inflammation or vision changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

macular degeneration wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NAMD)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

AOU delle Marche
RECRUITING

Ancona, 60126, Italy
Adelaide Eye and Retina Centre
RECRUITING

Adelaide, SA 5000, Australia
Aibili - Cec
RECRUITING

Coimbra, Portugal
Augenzentrum Frankfurt
RECRUITING

Frankfurt, 60549, Germany
Austin Clinical Research
RECRUITING

Austin, Texas, 78750, United States
Bajcsy-Zsilinszky Kórház
RECRUITING

Budapest, 1106, Hungary
Barnet Dulaney Perkins Eye Center
RECRUITING

Sun City, Arizona, 85351, United States
Bay Area Retina Associates
RECRUITING

Walnut Creek, California, 94598, United States
Black Hills Regional Eye Institute
RECRUITING

Rapid City, South Dakota, 57701, United States
Bradford Royal Infirmary
RECRUITING

Bradford, UK, BD9 6TB, United Kingdom
Budapest Retina Associates
RECRUITING

Budapest, Hungary
Carolina Eyecare
RECRUITING

Mt. Pleasant, South Carolina, 29464, United States
Centro Privado de Ojos
RECRUITING

Buenos Aires, 1033, Argentina
Centrovisión
RECRUITING

Mendoza, 5500, Argentina
Charles Research Center
RECRUITING

Buenos Aires, 1116, Argentina
Charleston Neuroscience Institute, LLC
RECRUITING

Bluffton, South Carolina, 29910, United States
Cincinnati Eye Institute
RECRUITING

Cincinnati, Ohio, 45242, United States
ClearVista Clinical Research
RECRUITING

Hudson, Florida, 34667, United States
Clinica Bonanova de Cirugía Ocular
RECRUITING

Barcelona, Spain
Cumberland Valley Retina Consultants
RECRUITING

Hagerstown, Maryland, 21740, United States
DE KK Ophthalmology Clinic
RECRUITING

Debrecen, Hungary
Dietrich Bonhoeffer Klinikum
RECRUITING

Neubrandenburg, 17036, Germany
East Florida Eye Institute
RECRUITING

Stuart, Florida, 34994, United States
Envision Ocular, LLC
RECRUITING

Bloomfield, New Jersey, 07003, United States
Erie Retina Research
RECRUITING

Erie, Pennsylvania, 16505, United States
Eye Clinic Albury Wodonga
RECRUITING

Albury, NSW 2640, Australia
Eye Clinic of Wisconsin
RECRUITING

Wausau, Wisconsin, 54403, United States
EyeHealth Northwest
RECRUITING

Portland, Oregon, 97233, United States
Florida Retina Institute
RECRUITING

Orlando, Florida, 32806, United States
Foundation for Vision Research
RECRUITING

Grand Rapids, Michigan, 49546, United States
Ganglion Medical Center
RECRUITING

Pécs, Hungary
Grupo Láser Visión
RECRUITING

Rosario, Santa Fe Province, 2000, Argentina
Hayashi Eye Hospital
RECRUITING

Fukuoka, Japan
Hospital Universitario Virgen Macarena
RECRUITING

Seville, Spain
Hospital of Lithuanian University of Health Sciences
RECRUITING

Kaunas, LT-50161, Lithuania
Illinois Retina Associates
RECRUITING

Oak Park, Illinois, 60304, United States
Internationale Innovative Ophthalmochirurgie GbR
RECRUITING

Düsseldorf, Germany
Kozawa Eye Hospital and Diabetes Center
RECRUITING

Mito, Ibaraki, 310-0845, Japan
Microcirugia Ocular Rosario
RECRUITING

Rosario, Santa Fe Province, 2000, Argentina
Mid Atlantic Retina Specialist
RECRUITING

Hagerstown, Maryland, 21740, United States
Miranza Instituto Gomez-Ulla
RECRUITING

Santiago de Compostela, Spain, 15706, Spain
National Hospital Organization Tokyo Medical Center
RECRUITING

Tokyo, 152-8902, Japan
New England Retina Consultants
RECRUITING

Springfield, Massachusetts, 01107, United States
New York Presbyterian Hospital - Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
North Carolina Retina Associates
RECRUITING

Cary, North Carolina, 27511, United States
North Carolina Retina Associates
RECRUITING

Wake Forest, North Carolina, 27587, United States
Northern California Retina Vitreous Associates
RECRUITING

Mountain View, California, 94040, United States
OFTALMOS
RECRUITING

Buenos Aires, 1830, Argentina
P.Stradins University Hospital
RECRUITING

Riga, Latvia
Pacific Northwest Retina
RECRUITING

Silverdale, Washington, 98383, United States
Palmetto Retina Center
RECRUITING

West Columbia, South Carolina, 29169, United States
Piedmont Eye Center
RECRUITING

Lynchburg, Virginia, 24502, United States
Research Network Arizona
RECRUITING

Scottsdale, Arizona, 85255, United States
Retina Associates
RECRUITING

Tucson, Arizona, 85704, United States
Retina Associates, Ltd.
RECRUITING

Elmhurst, Illinois, 60126, United States
Retina Consultants of Orange County
RECRUITING

Fullerton, California, 92835, United States
Retina Consultants of Southern Colorado P.C.
RECRUITING

Colorado Springs, Colorado, 80909, United States
Retina Partners Midwest, PC
RECRUITING

Carmel, Indiana, 46032, United States
Retina Specialty Institute
RECRUITING

Pensacola, Florida, 32503, United States
Retina Vitreous Associates of Florida
RECRUITING

St. Petersburg, Florida, 33711, United States
Retina Vitreous Associates of Florida
RECRUITING

Tampa, Florida, 33617, United States
Retina Vitreous Surgeons of CNY PC
RECRUITING

Liverpool, New York, 13088, United States
Retinal Consultants Medical Group
RECRUITING

Sacramento, California, 95841, United States
Retinal Consultants Medical Group Inc.
RECRUITING

Sacramento, California, 95825, United States
Retinal Diagnostic Center
RECRUITING

Campbell, California, 95008, United States
Riga East University hospital
RECRUITING

Riga, Latvia
Rocky Mountain Retina Consultants
RECRUITING

Salt Lake City, Utah, 84107, United States
Semmelweis Egyetem - Szemészeti Klinika
RECRUITING

Budapest, Hungary
Sierra Eye Associates
RECRUITING

Reno, Nevada, 89502, United States
Singapore Eye Research Institute (SERI)
RECRUITING

Singapore, Singapore
Social Medical Corporation Foundation Chiyuukai Fukuoka Wajiro Hospital
RECRUITING

Fukuoka, 811-0213, Japan
Southwest Retina Consultants
RECRUITING

Durango, Colorado, 81303, United States
Southwest Retina Specialist - Panhandle Eye group, LLP
RECRUITING

Amarillo, Texas, 79106, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62703, United States
Strategic Clinical Research
RECRUITING

Willow Park, Texas, 76087, United States
Strathfield Retina Clinic
RECRUITING

Strathfield, NSW 2135, Australia
Sunderland Eye Infirmary
RECRUITING

Sunderland, SR2 9HP, United Kingdom
Sydney Retina Clinic and Day Surgery
RECRUITING

Sydney, NSW 2000, Australia
SzTE SZAKK Szemeszeti Klinika
RECRUITING

Szeged, Hungary
Tan Tock Seng Hospital TTSH
RECRUITING

Singapore, Singapore
Tennessee Retina, PC
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Retina Associate
RECRUITING

Dallas, Texas, 75231, United States
The Retina Care Center
RECRUITING

Baltimore, Maryland, 21209, United States
The Retina Clinic London
RECRUITING

London, United Kingdom
Thomas Eye Group
RECRUITING

Sandy Springs, Georgia, 30328, United States
Tyler Retina Consultants
RECRUITING

Tyler, Texas, 75703, United States
University Retina and Macula Associates, PC
RECRUITING

Oak Forest, Illinois, 60452, United States
University of the Ryukyus Hospital
RECRUITING

Ginowan, Okinawa, 901-2725, Japan
Verum Research, LLC
RECRUITING

Eugene, Oregon, 947401, United States
Vilnius University Hospital Santaros Klinikos
RECRUITING

Vilnius, Lithuania
Vitreoretinal Consultants of NY
RECRUITING

Westbury, New York, 11590, United States
West Coast Retina Medical Group
RECRUITING

San Francisco, California, 94109, United States
Ziemekurzemes Regionala Slimnica
RECRUITING

Ventspils, Latvia
Zora Eye Hospital
RECRUITING

Sofia, Bulgaria

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