Custom 3D printed membrane aims to regrow jaw bone for dental implants
NCT ID NCT06186232
First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time
Summary
Researchers at Cairo University are testing whether a custom 3D printed PMMA membrane can help regrow bone in the upper jaw of people with a thin jaw ridge. Ten healthy adults with missing teeth in the aesthetic zone will receive guided bone regeneration using the membrane, then a dental implant six months later. The team will measure bone gain with CT scans and examine a small bone sample to check quality.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a custom 3D printed polymethylmethacrylate (PMMA) membrane used in guided bone regeneration
- What this could lead to
- If it works, custom 3D printed membranes could offer a more predictable way to rebuild jaw bone before dental implants, possibly reducing the need for bone grafts taken from elsewhere in the body.
- What could go wrong
- This is a small study of 10 people at one center, so results may not apply broadly. Bone regrowth varies between individuals, and the membrane could fail to hold enough bone for an implant.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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10 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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May 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with edentulous area related to horizontally deficient aesthetic zone of maxilla. * Patients are physically healthy with no medical history of any systemic or local disease that would contraindicate ridge augmentation and/or implant surgery or complicate the healing process. (Severe liver or kidney disease, a history of head and neck radiotherapy, chemotherapy at the time of surgery, uncontrolled diabetes, active periodontal in the residual dentition, inflammatory or autoimmune disorders of the oral mucosa, poor oral hygiene, patient failure to cooperate, and any other disease condition contraindicating the oral surgery). * Non-smokers. * Free from temporomandibular joint disorders and abnormal oral habits such as bruxism. * The edentulous ridges were covered with optimal thickness of keratinized mucosa with no signs of inflammation, ulceration or scar tissue. * The occlusion shows sufficient inter-arch space for future prothesis. Exclusion Criteria: * General contraindications to surgery. * Patients subjected to irradiation in the head and neck area less than 1 year before fixation. * Untreated periodontitis. * Poor oral hygiene. * Uncontrolled diabetes. * Pregnant or nursing. * Substance abuse. * Psychiatric problems or unrealistic expectations. * Severe bruxism or clenching. * Immunosuppressed or immunocompromised. * Treated or under treatment with intravenous amino-bisphosphonates. * Patients participating in other studies, if the present protocol could not be properly followed
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University
Cairo, Cairo Governorate, 11553, Egypt
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