Spyre Therapeutics, Inc.

This study is testing three long-acting antibodies, alone or in combination, in 645 people with ulcerative colitis. The goal is to see if they are safe and can improve bowel inflammation over 48 weeks. Participants are joining from a previous study and may have already seen some …

This Phase 2 study tests an experimental drug called SPY002-072 in 285 adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. Participants receive either the drug or a placebo, and researchers measure changes in disease ac…

This early-stage study tests the safety and how the body handles a new drug called SPY002-091. It involves 50 healthy adults who receive either the drug or a placebo. The main goal is to check for side effects and measure drug levels in the blood.

This early-stage trial tests the safety of a single dose of SPY003-207 in 59 healthy adults. Participants are randomly assigned to receive either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The goal is to gather initial…