Could a brain hormone curb alcohol cravings and lift depression at the same time?
Disease control
Not yet recruiting
This trial tests whether pregnenolone, a natural hormone, can help adults with both alcohol use disorder and major depression. Participants take either pregnenolone or a placebo for 12 weeks, while researchers track drinking, cravings, and mood. Brain scans will also look at how …
Phase: PHASE2 • Sponsor: Sherwood Brown, MD, PhD • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC