Microneedling boosts melasma treatments: could metformin or tranexamic acid outperform standard creams?
Disease control
ENROLLING_BY_INVITATION
This study compares three topical treatments—metformin, tranexamic acid, and a modified Kligman's formula—delivered via microneedling for facial melasma in adult women. Eighty participants are randomly assigned to one of four groups, including a saline control. The main goal is t…
Phase: PHASE4 • Sponsor: Sameh Sarsik • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC