Old antihistamine, new trick: could tripelennamine cream outperform diphenhydramine for itch?
Symptom relief
Completed
This study tests whether a topical cream containing tripelennamine, an older antihistamine, can relieve itching caused by histamine. Healthy adults aged 18 to 50 will have the cream applied to their forearms before a histamine challenge, and their itch intensity and skin reaction…
Early phase 1 • Sponsor: Palm Beach Atlantic University • Aim: Symptom relief
Last updated Aug 23, 2026 00:00 UTC