Can a second diuretic boost recovery from heart failure?
Disease control
Recruiting now
This trial investigates whether adding either metolazone or acetazolamide to standard loop diuretics helps adults hospitalized with acute heart failure and fluid overload. Participants are randomly assigned to one of three treatment arms, and the study tracks days alive and out o…
Phase 4 • Sponsor: Johannes Grand • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC